Antimicrobial Effects of Aqueous and Hydro-Alcoholic Plantago psyllium leaf extracts on the Experimental Infection of Helicobacter pylori in a Rat Model
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 269
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شناسه ملی سند علمی:
JR_ZUMS-29-137_002
تاریخ نمایه سازی: 1 آبان 1400
چکیده مقاله:
Background and Objective: Plantago psyllium has long been utilised as a medicinal agent worldwide. The current study aims to evaluate the in vivo antimicrobial effects of aqueous P. psyllium and a hydro-alcoholic extract of P. psyllium on Helicobacter pylori as well as the effects of these extracts on liver and kidney in a rat model.
Materials and Methods: A total number of ۵۰ female Sprague Dawley rats were experimentally infected (Except for the negative control group). The rats were divided into five groups of ۱۰. The groups were treated by Aqueous and Hydro-Alcoholic P. psyllium leaf extracts. Subsequently, H. pylori antigens which were present in the in rats’ stool were measured using a serological assay. To diagnose the pathogenicity of the kidney and liver, blood samples which had been taken before and after treatment, were tested for renal and hepatic enzymes by Analyzer Electrolyte and Sysmex KX-۲۱N.
Results: Following the amoxicillin treatment, the levels of aqueous and hydro-alcoholic extracts of the treated rats were compared with those of the control group, and a significant difference was observed (P<۰.۰۵). Antigen decrease was observed in all of the groups treated with amoxicillin (P=۰.۰۰۰۴), aqueous, and hydro-alcoholic extracts (P<۰.۰۵). Antigen decrease in the stool was observed in all groups, which indicates that treatment with the herbal extract could affect the infected rats.
Conclusion: P. psyllium hydro-alcoholic extract can be applied as a selective treatment for H. pylori infection. Hopefully, experiments suggested that the mentioned extracts could positively affect the process of disease recovery.
کلیدواژه ها:
نویسندگان
Shima Keshavarzi
Dept. of Microbiology, Fars Sciences and Research Branch, Islamic Azad University, Shiraz, Iran
Masoud Sepehrimanesh
Dept. of Biology, University of Louisiana at Lafayette, Louisiana, USA
Bahman Mirzaei
Dept. of Medical Microbiology and Virology, Faculty of Medicine, Mazandaran University of Medical Science, Sari, Iran
Omid Kuhi Hossein Abadi
Central Laboratory, Shiraz University of Medical Sciences, Shiraz, Iran
Zeynab Sardari
Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Mohammad Mehdi Sajjadpur
Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
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