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مقالات فارسیISIکنفرانسهاژورنالها

Involvement of brain-derived neurotrophic factor (BDNF) on malathion induced depressive-like behavior in subacute exposure and protective effects of crocin

محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 18، شماره: 10
سال انتشار: 1394
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 208

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لینک ثابت به این مقاله:
https://civilica.com/doc/1297019

شناسه ملی سند علمی:

JR_IJBMS-18-10_003

تاریخ نمایه سازی: 3 آبان 1400

چکیده مقاله:

Objective(s): In this study the effect of crocin, a carotenoid isolated from saffron, on malathion (an organophosphate insecticide) induced depressive- like behavior in subacute exposure was investigated. Moreover the molecular mechanism of malathion induced depressive- like behavior and its decreasing effect on the level of brain derived neurotrophic factor (BDNF) in rat hippocampus and cerebral cortex were evaluated. Materials and Methods: Male Wistar rats were exposed to malathion (۵۰ mg/kg/day, IP) alone or in combination with crocin (۱۰, ۲۰ and ۴۰ mg/kg/day, IP), imipramine (۲۰ mg/kg/day, IP) and vitamin E (۲۰۰ mg/kg, three times a week, IP) respectively for ۱۴ days. The forced swimming test (FST) was performed on days ۱st, ۷th and ۱۴st. The level of malondealdehyde (MDA) and reduced glutathione (GSH) were measured in cerebral cortex and hippocampus of rats. The protein level of BDNF was evaluated using Western blot analysis. Results: Malathion (۵۰ mg/kg, IP) increased immobility time in the FST, without affecting total locomotor activity in open-field test. Malathion increased the malondealdehyde (MDA) and decreased the glutathione (GSH), whereas these effects were reversed by crocin and vitamin E. Malathion decreased plasma acetylcholinesterase  activity,  however  this effect was not reversed by crocin or vitamin E. Malathion reduced the protein level of BDNF in rat hippocampus. Imipramine and crocin  prevented the decreasing effect of malathion on BDNF. Conclusion: These results showed that crocin attenuates some neurochemical and behavioral effects induced by malathion. This neuroprotective effect of crocin may be in part due to its effect on BDNF.

کلیدواژه ها:

BDNF ، Crocin ، Depression ، Forced swimming test ، Malathion ، Saffron

نویسندگان

Somaye Ardebili Dorri

School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Hossein Hosseinzadeh

Pharmaceutical Research Center, Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Khalil Abnous

Pharmaceutical Research Center, Department of Medicinal Chemistry, Mashhad University of Medical Sciences, Mashhad, Iran

Faezeh Vahdati Hasani

School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Rezvan Yazdian Robati

School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Bibi Marjan Razavi

Targeted Drug Delivery Research Center, Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

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  • Hisaoka K, Maeda N, Tsuchioka M, Takebayashi M. Antidepressants induce ...
  • Aydemir O, Devecia A, Tanelib F. The effect of chronic ...
  • Soeda S, Ochiai T, Shimeno H, Saito H, Abe K, ...
  • Fernández J. Anticancer properties of saffron, Crocus sativus Linn. Adv ...
  • Assimopoulou A, Sinakos Z, Papageorgiou V. Radical scavenging activity of ...
  • Hosseinzadeh H, Shamsaie F, Mehri S. Antioxidant activity of aqueous ...
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  • Hosseinzadeh H, Khosravan V. Anticonvulsant effects of aqueous and ethanolic ...
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  • Akhondzadeh S, Fallah-Pour H, Afkham K, Jamshidi A, Khalighi-Cigaroudi F. ...
  • Vahdati Hassani F, Naseri V, Razavi BM, Mehri S, Abnous ...
  • Sanchez-Mateo C, Bonkanka C, Prado B, Rabanal R. Antidepressant activity ...
  • Hadizadeh F, Mohajeri S, Saifi M. Extraction and purification of ...
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  • Pardon M. Perez Diaz F, Joubert C, Cohen Salmon C. ...
  • Fernandez J, Perez-Alvarez J, Fernandez-lopez J. Thiobarbituric acid test for ...
  • Moron M, Depierre J, Mannervik B. Levels of glutathione, glutathione ...
  • Rezg R, Mornagui B, El-Fazaa S, Gharbi N. Biochemical evaluation ...
  • Chen N, Luo D, Yao X, Yu C, Wang Y, ...
  • Brocardo P, Assini F, Franco J, Pandolfo P, Muller M, ...
  • Ramos ZR, Fortunato JJ, Agostinho FR, Martins MR, Correa M, ...
  • Walsh RN, Cummins RA. The open-field test: A critical review. ...
  • Assini FL, Zanette KD, Brocardo PS, Pandolfo P, Rodrigues ALS, ...
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  • Akhgari M, Abdollahi M, Kebryaeezadeh A, Hosseini R, Sazevari O. ...
  • Possamai FP, Fortunato JJ, Feier G, Agostinho FR, Quevedo J, ...
  • Fortunato J J, Feier G, Vitali A, Petronilho F, Dal-Pizzol ...
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  • Abdollahi M, Mostafalou S, Pournourmohammadi SH, Shadnia SH. Oxidative stress ...
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