Effects of treadmill exercise training on cerebellar estrogen and estrogen receptors, serum estrogen, and motor coordination performance of ovariectomized rats
محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 18، شماره: 6
سال انتشار: 1394
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 150
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شناسه ملی سند علمی:
JR_IJBMS-18-6_009
تاریخ نمایه سازی: 3 آبان 1400
چکیده مقاله:
Objective(s): The present study aims at examining the motor coordination performance, serum and cerebellar estrogen, as well as ERβ levels, of ovariectomized rats (as menopausal model) following regular exercise. Materials and Methods:Ten female Sprague Dawley ratsaged ۱۲ weeks old were randomly divided into two groups; all of which underwent ovariectomy. The first group was treated with regular exercise of moderate intensity, in which the rats were trained to run on a treadmill for ۶۰ min per day for ۱۲ weeks. The second group served as control. Rotarod test was carried out before and after exercise treatment. All rats were euthanized thereafter, and blood and cerebellums of the rats were collected. The serum and cerebellar estrogen as well as cerebellar ERβ levels were measured using ELISA assays. Results: The number of falls in the rotarod task of the exercise group was significantly lower than that of control group. The cerebellar estrogen level of the exercise group was significantly higher than that of control group. Accordingly, there was a significantly negative correlation between the number of falls and cerebellar estrogen level in the exercise group. Conclusion:The present study shows that a lengthy period of regular exercise improves the cerebellar estrogen level and motor coordination performance in ovariectomized rats.
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نویسندگان
Saidah Rauf
Department of Physiology, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia
Sri Kadarsih Soejono
Department of Physiology, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia
Ginus Partadiredja
Department of Physiology, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia
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