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Adiponectin: an adipokine with protective features against metabolic syndrome

محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 18، شماره: 5
سال انتشار: 1394
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 163

فایل این مقاله در 13 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1297128

شناسه ملی سند علمی:

JR_IJBMS-18-5_002

تاریخ نمایه سازی: 3 آبان 1400

چکیده مقاله:

Metabolic syndrome (MetS) as a collection of obesity-associated disorders is associated with inflammation, oxidative stress, pro-thrombotic state, elevated risk of developing cardiovascular disease and type ۲ diabetes. Adiponectin is one of the most abundant peptide hormones derived from adipose tissue. This protein plays a major role in glucose and lipid metabolism and prevents development of vascular changes. Anti-oxidative and anti-inflammatory effects are the other features of adiponectin. Hypoadiponectinemia is associated with hypertension and pro-thrombotic state. In this review, we discuss the crucial role of adiponectin in prevention of metabolic syndrome considering its effects on the components of this syndrome. Pharmacological interventions and lifestyle modification may increase plasma adiponectin level or tissue sensitivity which seems to be a promising target for prevention and therapeutic approaches of MetS and related diseases.

کلیدواژه ها:

Adiponectin ، Atherosclerosis ، Hypertension ، Inflammation ، metabolic syndrome ، Oxidative stress

نویسندگان

Maryam Esfahani

Department of Clinical Biochemistry, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran

Ahmad Movahedian

Department of Clinical Biochemistry, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran

Mostafa Baranchi

Department of Physical Education and Sports Sciences, Tarbiat Modares University, Tehran, Iran

Mohammad Taghi Goodarzi

Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

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