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مقالات فارسیISIکنفرانسهاژورنالها

Investigation of FOXP۳ genetic variations at positions -۲۳۸۳ C/T and IVS۹+۴۵۹ T/C in southern Iranian patients with lung carcinoma

محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 18، شماره: 5
سال انتشار: 1394
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 148

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لینک ثابت به این مقاله:
https://civilica.com/doc/1297132

شناسه ملی سند علمی:

JR_IJBMS-18-5_006

تاریخ نمایه سازی: 3 آبان 1400

چکیده مقاله:

Objective(s): FOXP۳ gene is an X-linked gene that encodes FOXP۳ protein, an essential transcription factor in CD۴+CD۲۵+FOXP۳+ regulatory T (Treg) cells.  We aimed, in the present study, to investigate the association of two FOXP۳ polymorphisms, -۲۳۸۳ C/T (rs۳۷۶۱۵۴۹) and IVS۹+۴۵۹ T/C (rs۲۲۸۰۸۸۳), with lung cancer. Materials and Methods:  In a case-control study we analyzed genotypes and alleles frequencies at -۲۳۸۳ C/T and IVS۹+۴۵۹ T/C positions in ۱۵۶ patients with lung cancer and ۱۵۶ age and sex matched healthy controls in Southern Iranian population, using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods. The data were verified by direct automated DNA sequencing. Results: The frequency of -۲۳۸۳ T allele was significantly higher in the patients than in the control group (۱۱.۸% versus ۵.۹%, P-value=۰.۰۴, OR=۲.۱۳, ۹۵%CI=۱.۰۴-۴.۵۴). T allele frequency at IVS۹+۴۵۹ T/C position was higher, compared to the controls, in the patients who presented the disease over ۵۵ years old (۶۹.۹% versus ۵۹.۱%, P-value=۰.۰۴, OR=۱.۶۱, ۹۵%CI=۱.۰۱-۲.۵۵) and also in SCLC patients (۷۷.۸% versus ۵۹.۱%, P-value=۰.۰۳, OR=۲.۴۲, ۹۵%CI=۱.۰۵-۵.۵۹). No significant differences were found in the genotypes and haplotypes distributions between the cases and controls. A high degree of linkage disequilibrium was observed between two polymorphisms.  Conclusion: As the first study dealing with -۲۳۸۳ C/T and IVS۹+۴۵۹ T/C in lung cancer, our data conclusively suggest the association of -۲۳۸۳ T allele with susceptibility to lung cancer in Iranian population. The association of IVS۹+۴۵۹ T allele with susceptibility to lung cancer in old patients suggests the age-dependent effects of FOXP۳ gene on cancer occurrence.

کلیدواژه ها:

FOXP۳ gene ، Gene polymorphism ، Lung cancer ، PCR-RFLP

نویسندگان

Maryam Fazelzadeh Haghighi

Cancer Immunology Group, Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Mohammad Ali Ghayumi

Department of Internal Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Farzane Behzadnia

Cancer Immunology Group, Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Nasrollah Erfani

Molecular Medicine Group, Graduate School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran

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