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Effect of Nigella sativa fixed oil on ethanol toxicity in rats

محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 17، شماره: 12
سال انتشار: 1393
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 219

فایل این مقاله در 12 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1297724

شناسه ملی سند علمی:

JR_IJBMS-17-12_013

تاریخ نمایه سازی: 4 آبان 1400

چکیده مقاله:

Objective(s):This study was planned to appraise the protective effect of Nigella sativa fixed oil (NSO) against subchronic ethanol induced toxicity in rats. Materials and Methods: Studies were carried out on six groups of six animals each, including control (normal saline, gavage), ethanol (۳ g/kg/day, gavage), NSO (۰.۱۲۵, ۰.۲۵ and ۰.۵ ml/Kg/day, IP) plus ethanol and NSO (۰.۵ ml/Kg/day, IP) groups. Treatments were continued for ۴ weeks. Results: According to data, treatment with NSO attenuated ethanol-induced increased levels of malondialdehyde (MDA), tumor necrosis factor α (TNF-α) and interleukin-۶ (IL-۶), as well as histopathological changes in liver and kidney tissues. Moreover, NSO improved the level of serum liver enzymes (including alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) and glutathione (GSH) content in liver and kidney tissues in ethanol-treated rats. Western blot analysis and quantitative real time RT-PCR showed that NSO treatment inhibited apoptosis stimulated by ethanol through decreasing the Bax/Bcl-۲ ratio (both protein and mRNA levels), cleaved caspase-۳, cleaved caspase-۸ and cleaved caspase-۹ level in liver and kidney. Conclusion: This study showed that NSO may have protective effects against hepatotoxicity and renal toxicity of ethanol by decreasing lipid peroxidation and inflammation and preventing apoptosis.

کلیدواژه ها:

Apoptosis ، Ethanol toxicity ، Lipid Peroxidation ، Nigella Sativa ، Oxidative stress ، Alcohol

نویسندگان

Hamed Pourbakhsh

Food Control Laboratory, Food and Drug Administration, Shiraz University of Medical Sciences, Shiraz, Iran

Elahe Taghiabadi

Department of Phamacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Khalil Abnous

Pharmaceutical Research Center, Department of Medicinal Chemistry, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Alireza Timcheh Hariri

Medical Toxicology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Sayed Masoud Hosseini

Department of Phamacodynamy and Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Hossein Hosseinzadeh

Pharmaceutical Research Center, Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

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