Hormonal and metabolic effects of polyunsaturated fatty acid (omega-۳) on polycystic ovary syndrome induced rats under diet
محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 17، شماره: 2
سال انتشار: 1393
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 185
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شناسه ملی سند علمی:
JR_IJBMS-17-2_008
تاریخ نمایه سازی: 5 آبان 1400
چکیده مقاله:
Objective(s): PCOS (polycystic ovary syndrome) produces symptoms in approximately ۵% to ۱۰% of women of reproductive age (۱۲–۴۵ years old). It is thought to be one of the leading causes of female subfertility. This study aimed to confirm the role of nutrition containing omega-۳ (polyunsaturated fatty acid) on control of experimental PCO induced by estradiol-valerat in rats. Materials and Methods: Wistar female rats (n=۴۰) were allocated into control (n=۱۰) and test groups (n= ۳۰), test group was subdivided into ۳ groups: G۱, received omega-۳ (۲۴۰ mg/kg/orally/daily); G۲ and G۳ groups were induced PCO by single injection of estradiol-valerate (۱۶ mg/kg/IM). Group ۳ received omega-۳ (۲۴۰ mg/kg/orally/daily) and low carbohydrate feeding for ۶۰ subsequent days; on sixtieth day ۵ ml blood samples and ovarian tissues of all rats in the group were removed and prepared for biochemical and hormonal analysis. Results: Catalase, GPX (Glutathione peroxidase), SOD (Superoxide dismutase) in groups that received omega-۳showed higher levels, but MDA (malondialdehyde) level was significantly decreased (P<۰.۰۵) in comparison with other experimental groups. Ovarian weights in both experimental and control groups were similar (P<۰.۰۵). Level of serum FSH (follicle stimulating hormone) was decreased, but level of testosterone was significantly increased (P<۰.۰۵) in PCO group in comparison with control and omega-۳ groups. Conclusion: Results revealed that administration of omega-۳ plus lower carbohydrate food significantly controlled PCO syndrome and balanced FSH and testosterone.
کلیدواژه ها:
Catalaze (CAT) ، Follicle stimulating hormone (FSH) ، Glutathione peroxidase (GPX) ، Omega-۳ ، Polycystic ovary (PCO) ، Super oxide dismutase (SOD) ، Testosterone
نویسندگان
Elaheh Ouladsahebmadarek
Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Arash Khaki
Department of Pathology, Tabriz Branch, Islamic Azad University, Tabriz, Iran
Sharareh Khanahmadi
Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Hamidreza Ahmadi Ashtiani
Department of Biochemistry, Islamic Azad University, Pharmaceutical, Tehran, Iran
Pooya Paknejad
Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Mohammad Reza Ayubi
Department of Pathology, Tabriz Branch, Islamic Azad University, Tabriz, Iran
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