Background and Obgective: Diabetic foot ulcer is a serious complication and if left untreated, it can cause irreparable problems for the patient. The present study was performed to determine the effect of topical
oxygen therapy on the healing of diabetic foot
ulcers Materials and Methods: In this one-blind and multicenter randomized clinical trial, ۴۰ patients admitted to Qazvin Educational and Medical Centers in ۱۳۹۸ were randomly assigned using coin toss and block randomization (five blocks and ten samples per block) in one They were divided into two groups of control and test (۲۰ people in each group). In the control group, the only daily care that included routine cares was performed by washing the wound with normal saline and then with dry sterile gauze and with conventional dressing products twice a day.In the experimental group, in addition to the above care, topical
oxygen therapy with direct use of high pressure dry
oxygen by
oxygen catheter at a distance of one centimeter from the wound, with a flow of ۱۰ liters per minute for ۲۰ minutes, three times a day for at least one It was the week. The condition of the wound (size, height and total score of the wound with the standard of push index) was evaluated after the intervention for at least one week in ۶ time points with an interval of ۴۸ hours, which due to the lack of cooperation of some patients Time (۷ days) was considered. Data were analyzed using SPSS software version ۲۳ and descriptive statistics, independent t-test and repeated measures analysis of variance. The present study has the code of ethics IR.QUMS.REC.۱۳۹۷.۳۹۵ and more ethical considerations are available on the IRCT website (registration number: IRCT۲۰۱۹۰۷۰۸۰۴۴۱۴۸N۱)Findings: Men made up ۸۵% of the control group and ۷۸.۹% of the intervention group. All patients had type ۲ diabetes. The size of the ankle brachial index was in the normal range in all patients. the results of analysis of variance showed that only the interaction of the two variables of height and total wound score was significant with time (P = ۰.۰۰۱ for height and P <۰.۰۰۱ for total score, respectively). Benfroni post hoc test showed that the depth and total score of the wound in the intervention group had a significantly stronger downward trend than the control group.Conclusion: Topical
oxygen therapy had no significant effect on wound size, but the depth and score of the whole wound was significant, indicating the positive effect of
oxygen therapy on wound healing. Extensive studies with longer intervals are recommended.