Stability Indicating Planar Chromatographic method for Estimation of Minoxidil and Finasteride Combination used in the treatment of Hair loss
محل انتشار: مجله علوم دارویی و شیمی، دوره: 4، شماره: 1
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 124
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شناسه ملی سند علمی:
JR_JMCH-4-1_003
تاریخ نمایه سازی: 8 آذر 1400
چکیده مقاله:
Alopecia areata is a typical non-scarring alopecia that happens in ۰.۱-۰.۲% of everybody and records for ۰.۷-۳% of all cases found in dermatology practice. A vital quantitative examination of Minoxidil and Finasteride was created in Bulk and pharmaceutical measurement structure with precise, and sensitive stability indicating high performance thin layer chromatographic (HPTLC) technique. The chromatographic improvement was done on the HPTLC plates precoated with silica gel ۶۰ F۲۵۴ utilizing a mobile phase of n-butanol: TEA (۱۰:۰.۱v/v) as versatile stage. Detection was completed densitometrically at ۲۲۳ nm. The Rf estimation of medication was seen as ۰.۲۲ ± ۰.۲۴ for Minoxidil and ۰.۶۳ ± ۰.۶۵ for Finasteride. The technique was approved according to the ICH rule concerning linearity, accuracy, precision and robustness. The calibration curve was seen as straight over a scope of ۶۰۰۰-۲۴۰۰۰ ng/band for Minoxidil and ۲۰۰-۸۰۰ ng/band for Finasteride with a regression coefficient of ۰.۹۹۷۲ For Minoxidil and ۰.۹۹۸ for finasteride. The % recovery was found ۹۸-۱۰۱.۹۲% for Minoxidil and ۹۸.۴۲-۱۰۱.۶۸% for Finasteride. Forced degradation studies like acid hydrolysis, base hydrolysis, oxidation, dry heat and photolytic degradation were performed. The degradation products obtained were well resolved from the pure drugs with significantly different Rf values. The proposed technique could viably isolate the medications from its degradation products just as from excipients. The proposed TLC technique has expected subjective just as quantitative applications for synchronous estimation of minoxidil and finasteride in bulk and pharmaceutical dosage form.
کلیدواژه ها:
نویسندگان
Jay Patel
Department of Pharmaceutical Chemistry and Analysis, Indukaka Ipcowala College of Pharmacy, New V. V. Nagar, Anand
Jinal Tandel
Department of Pharmaceutical Chemistry and Analysis, Indukaka Ipcowala College of Pharmacy, New V. V. Nagar, Anand
Usmangani Chhalotiya
Department of Pharmaceutical Chemistry and Analysis, Indukaka Ipcowala College of Pharmacy, New V. V. Nagar, Anand
Kirtan Patel
Department of Pharmaceutical Chemistry and Analysis, Indukaka Ipcowala College of Pharmacy, New V. V. Nagar, Anand
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