Spectrophotometric first order derivative method for simultaneous determination of etoricoxib and paracetamol in tablet dosage form

This work was aimed to develop a new, sensitive, accurate, precise, and simple UV spectrophotometric method for estimating the Etoricoxib and Paracetamol in tablet dosage form. Firstorder derivative simultaneous estimation was carried out by using the UV-visible double beam spectrophotometer. Etoricoxib and Paracetamol exhibited absorbance at working wavelength ۲۴۸ nm (Zero crossing point of Paracetamol) and ۲۵۸.۴ nm (Zero crossing point of Etoricoxib), respectively, using methanol as a solvent. Linearity was found ۱-۸ μg/mL for Etoricoxib and ۵.۴۲-۴۳.۳ μg/mL for Paracetamol. Accuracy was obtained between ۹۸.۹۶ to ۱۰۱.۳۸% for Etoricoxib and ۹۸.۳۸ to ۱۰۱.۶۴% for Paracetamol. LOD an LOQ was found to be ۰.۱۲۲ μg/mL and ۰.۲۴۸ μg/mL for Etoricoxib and ۰.۰۷۵ μg/mL and ۰.۱۵۲ μg/mL for Paracetamol. The developed method was validated as per ICH Guideline. The results confirmed that the proposed method is suitable for the routine analysis for the estimation of Etoricoxib and Paracetamol in tablet dosage form.