Antidiabetic activity of Ethanolic extract of CALAMUS ROTANG LINN leaves

The plant Calamus rotang linn belonging to the family of Arecaceae is claimed to have medicinal uses such as astringent, antidiarrhoeal, anti-inflammatory, tumours, convulsions and diabetes. The purpose of the present study was to assess the antidiabetic effect of EECRL on normal and diabetic rats.The preliminary phytochemical studies indicate the presence of carbohydrates, alkaloids, saponins, flavonoids, tannins & phenolic compounds.The Oral administration of EECRL ۱۰۰, ۲۰۰ mg/kg to the diabetic rats significantly reduced blood glucose level by STZ-NC induced rat model. The body weigh also restored to normal level. Histopathology of pancreas shows marked proliferated and regenerated β-cells in EECRL treated rats. All the above parameters were comparable to the standard drug glibenclamide.Hence, above findings have given scientific evidence to the traditional use of Calamus rotang linn leaves in the treatment of diabetes. Further studies are required to identify the active constituents and to work out exact mechanism of action involved in antidiabetic potential.