The role of molecular factors in gestational hypertension and the pathogenesis of preeclampsia
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 170
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شناسه ملی سند علمی:
JR_CAJMPSI-1-6_004
تاریخ نمایه سازی: 11 دی 1400
چکیده مقاله:
Preeclampsia (PE) is classified as a systemic condition that generally develops with high blood pressure and protein excretion in pregnant women after ۲۰ weeks. This condition is characterised by inadequate placental blood flow and damages several organs. The illness is a complicated ailment that starts with an aberrant trophoblast invasion of the uterine decidua, endothelial dysfunction, and platelet aggregation, finally leading to a faulty placenta. Defective placenta causes difficulties such as hypoxia, oxidative stress, stimulation of the mother's immune system, and some other situations. Although the specific origin of this illness has not yet been discovered, various cellular signalling pathways may be implicated in its development. One of the molecules that may be implicated in preeclampsia is the sFlt-۱ molecule. This protein has an inhibitory influence on vascularization of the placenta by lowering signalling VEGF, which leads to apoptosis of foetal vascular and disrupted placenta and exchange of nutrients, which finally leads to foetal growth limitation and preeclampsia. The renin-angiotensin-aldosterone pathway, inflammatory cytokines, and the Nrf۲/HO-۱ pathway are also implicated in the pathophysiology of this condition. The biogenesis route of microRNAs involved in controlling gene expression might be regarded as extra variables implicated in preeclampsia. The goal of this work was to elucidate the molecular components involved in the pathophysiology of preeclampsia.
کلیدواژه ها:
نویسندگان
Kambiz Kamyab Hesari
Department of Pathology, School of Medicine,Tehran University of Medical Sciences, Tehran, Iran
Melika Molkizadeh
Mashhad Paramedical Science Branch, Islamic Azad University, Mashhad, Iran
Amirkian Bokharaei
Student Research Committee, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
Farnaz Mohajertehran
Department of Oral and Maxillofacial Pathology, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
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