Sarcoma in a Patient with Laryngeal Papillomatosis: A Case Report

Introduction:Recurrent respiratory papillomatosis (RRP) is classically described as a benign neoplasm of the larynx. Nevertheless, transformation to dysplasia and invasive carcinoma can occur. Sarcoma of the larynx is rare. Here, we present a case of sarcoma in a patient repeatedly treated for RRP. Case Report:We report a case of a ۷۳- year old Caucasian male diagnosed with adult-onset recurrent respiratory papillomatosis (AORRP) at the age of ۶۳y. o. During the previous ۱۰ years, he underwent multiple surgeries. In the last therapeutic intervention, he was treated with laser excision of the papilloma and topical mitomycin application. Two months after treatment, papilloma recurred and sarcoma was diagnosed.Conclusions:RRP is a benign lesion.  Affected patients usually require multiple interventions. It rarely degenerates to malignancy. Sarcoma in the larynx in the presence of RRP is a rare case. Extended surgical removal remains the treatment of choice. Adjuvant therapies consist of chemotherapy and radiation and are reserved for unresectable or recurrent cases.