Production of Strontium-۸۹ Radioisotope by Neutron Activation Method and Preparation of ۸۹Strontium Chloride Radiopharmaceutical

M Moosavi; S Setayeshi; S.J Ahmadi; M.R Kardan; R Gholipour Peyvandi; A Bahrami Samani; B Salimi; A Abbasi; S.M Mazidi; S.H Mirfallah; M Ghannadi Maragheh

Production of Strontium-۸۹ Radioisotope by Neutron Activation Method and Preparation of ۸۹Strontium Chloride Radiopharmaceutical

محل انتشار: مجله علوم و فنون هسته ای، دوره: 30، شماره: 1

سال انتشار: 1388

نوع سند: مقاله ژورنالی

زبان: فارسی

مشاهده: 94

متن کامل این مقاله منتشر نشده است و فقط به صورت چکیده یا چکیده مبسوط در پایگاه موجود می باشد.
توضیح: معمولا کلیه مقالاتی که کمتر از ۵ صفحه باشند در پایگاه سیویلیکا اصل مقاله (فول تکست) محسوب نمی شوند و فقط کاربران عضو بدون کسر اعتبار می توانند فایل آنها را دریافت نمایند.

صدور گواهی نمایه سازی
من نویسنده این مقاله هستم

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:

https://civilica.com/doc/1365629

شناسه ملی سند علمی:

JR_JONSAT-30-1_009

تاریخ نمایه سازی: 12 دی 1400

چکیده مقاله:

Strontium-۸۹ is one of the most important radioisotopes used in nuclear medicine for therapy of bone pain caused by bone metastases. That is due to the beta radiation with sufficient energy for destroying metastatic sites in bone tissue. The routine application is ensured by introducing ۸۹SrCl۲ radiopharmaceutical and then injection of a specific dose in human vein, where it leads to reduction of bone pains. In this research, ۸۹Sr was produced in the Tehran Research Reactor (TRR) for both natural Sr (includes ۸۴Sr and ۸۸Sr) and enriched Sr (includes ۸۸Sr of %۹۹ purity) for the comparison and preparation of ۸۹SrCl۲ radiopharmaceutical. Natural radioactivated Sr which produces gamma radiation was injected in mice and then based on gamma spectroscopy in different tissues, a calculation was made for the dose absorption rate, defined by %ID/g. Also, radioactivated enriched Sr-۸۸ was injected in mice and the %ID/g was calculated due to distribution of the beta radiation in mice tissues. In our biodistribution we observed a rapid blood clearance followed by the high absorption of activity in bone tissues. These data have shown that the prepared compound is a well defined radiopharmaceutical for the bone pain palliation in metastatic lesions.

کلیدواژه ها:

Strontium-۸۹ ، Strontium Chlorides ، Neutron Activation Analysis ، Therapy of Bone Metastases ، Gamma radiation ، Beta Radiation

نویسندگان

M Moosavi

۱- Nuclear Engineering and Physics Department, Amir Kabir University, P.O.Box: ۱۵۸۷۵-۴۴۱۳, Tehran-Iran ۲- Chemistry Research Group, Nuclear Science Research School, Nuclear Science and Technology Research Institute, P.O.Box: ۱۱۳۶۵-۸۴۸۶, Tehran-Iran

S Setayeshi

۱- Nuclear Engineering and Physics Department, Amir Kabir University, P.O.Box: ۱۵۸۷۵-۴۴۱۳, Tehran-Iran

S.J Ahmadi