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Evaluation of the anti-melanogenic activity of nanostructured lipid carriers containing auraptene: A natural anti-oxidant agent

محل انتشار: مجله علوم نانو، دوره: 9، شماره: 1
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 251

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استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1372014

شناسه ملی سند علمی:

JR_NAMJ-9-1_006

تاریخ نمایه سازی: 19 دی 1400

چکیده مقاله:

Objective(s): In this work, we loaded Auraptene (AUR) into nanostructured lipid carriers (NLCs) and performed an assessment on inhibitory activities of the obtained AUR-NLCs on melanogenesis. Materials and Methods: AUR-NLCs were prepared through a high shear homogenization and ultrasound method. Results: Entrapment efficiency and Particle size of the optimized formulation were ۱۰۳.۱±۴.۹ nm and ۸۹.۵۶±۳.۷۵. The TEM outcomes exhibited the spherical shape of our nanoparticles, while the DSC analysis revealed the lack of any drug-lipid incompatibility throughout the formulations. A prolonged drug-release was observed from AUR-NLCs when compared to the AUR-solution. According to results, this product can significantly attenuated the activity of cellular tyrosinase and ROS content with minimal cytotoxic effects in B۱۶F۱۰ cell line, which in contrast to AUR-solution. Moreover, the western blotting analysis was indicative of AUR-NLCs ability to inhibit melanogenesis through the suppression of MITF and act much more efficiently than AUR-solution.Conclusion: AUR-NLCs can offer merits as a natural anti-tyrosinase agent for the treatment of hyperpigmentory disorders.

کلیدواژه ها:

Anti-tyrosinase ، Auraptene ، Melanin ، Melanogenesis ، NLC

نویسندگان

Sara Daneshmand

Department of Pharmaceutics, School of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran

Reavan Yazdian-Robati

Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Mahmoud Reza Jaafari

Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

Jebraeel Movafagh

Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

Bizhan Malaekeh-Nikouei

Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

Mehrdad Iranshahi

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

Shiva Golmohammadzadeh

Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

Zahra Tayarani-Najaran

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

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