LSPR based biosensor for pancreatic cancer’s detection

This work reports the fabrication of gold nanoparticles on a glass substrate via a high-temperature annealing method for designing a localized surface plasmon resonance (LSPR) biosensor. To obtain gold nanoparticles, a thin film of gold with different thicknesses has been deposited on a glass substrate using the magnetron sputtering method. Then, an eight-hour annealing process has been performed at different temperatures close to the glass transition temperature to form gold nanoparticle islands on the glass substrate. Then, CA-۱۹-۹ antibodies are immobilized on gold nanostructures and the identification of the specific antigens are evaluated by the corresponding wavelength shift in LSPR peak wavelength and the light intensity changes.