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مقالات فارسیISIکنفرانسهاژورنالها

The Predictive Value of Serum NGAL for the Diagnosis of Delayed Graft Function in Kidney Transplantation

محل انتشار: فصلنامه تحقیقات بین رشته ای در اورولوژی، دوره: 3، شماره: 4
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 210

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لینک ثابت به این مقاله:
https://civilica.com/doc/1380014

شناسه ملی سند علمی:

JR_TUMS-3-4_008

تاریخ نمایه سازی: 29 دی 1400

چکیده مقاله:

Introduction: The role of serum neutrophil gelatinase-associated lipocalin (NGAL) in predicting delayed graft function (DGF) after kidney transplantation is poorly defined. The objective of this study was to evaluate the serum NGAL expression in the early postoperative phase after kidney transplantation and compare it with serum creatinine (Cr).Methods: We studied ۲۹ patients who received kidney transplantation from deceased (n=۲۴) and lived (n=۵) donors from October ۲۰۱۷ to December ۲۰۱۸ at the Urology Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran. Serum NGAL, Serum Cr, and urine output were measured at ۱ to ۷ days after transplantation. The need for dialysis in one week after transplantation was evaluated.Results: Among ۲۹ recipients with serum biomarkers measurements, ۸ (۲۷.۵%) developed DGF (need to hemodialysis within one week of transplantation). Resulted in areas under ROC curves (AUCs) for serum NGAL at early hours following transplantation was (۰.۸۳۹, ۹۵% CI: ۰.۶۹-۰.۹۸, P-value=۰.۰۰۵) that could accurately predict DGF compared to urine output (۰.۷۴۷, ۹۵% CI: ۰.۵۵-۰.۹۳, P-value=۰.۰۴۵) and serum Cr (۰.۶۰۷, ۹۵% CI: ۰.۳۴-۰.۸۶, P-value=۰.۳۹۸) at ۲۴ hours after transplantation. Multivariate analysis revealed that only serum NGAL was a significant independent predictor of DGF (OR: ۰.۹۹۶, ۹۵% CI: ۰.۹۹۳-۱.۰۰۰, P-value=۰.۰۳۹).  Conclusion: Serum NGAL at early hours of post-transplantation was a valuable biomarker for an early accurate predictor of DGF in kidney transplantation compared with traditional biomarkers such as serum Cr and urine output.

کلیدواژه ها:

Kidney Transplantation ، delay graft function ، serum NGAL ، predictive biomarkers

نویسندگان

Gholamreza Pourmand

Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran

Behrouz Emamjomeh

Department of Geriatric Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Alireza Namazi Shabestari

Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Shahram Gooran

Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran

Farshad Namdari

Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran

Abdolrasoul Mehrsai

Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran

Sanaz Dehghani

Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran

Venous Soleimani

Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran

Maryam Aghaii

Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran

Farzaneh Bagherpour

Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran

Fariba Heidari

Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran

Sara Ashtari

Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Rahil Mashhadi

Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran

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