Investigation of the P۱۶ and Ki۶۷ Predictive Effect on the Progression of Cervical Intraepithelial Neoplasia Grade ۱ in Shahid Motahari Hospital of Urmia, Iran

Background and Objective: Cervical cancer is a common neoplasm in women, and the role of the HPV virus in the development of precancerous and cancerous cells has been established. There exist different strains of the HPV virus with varied functions. In the high-risk HPV strains, the p۱۶ and ki۶۷ proteins play a crucial role in regulating the cell cycle leading to cell proliferation and progression. P۱۶ and ki۶۷ proteins are positive in almost all lesions and indicate a high degree of malignancy. This study aims to investigate the predictive effect of p۱۶ and ki۶۷ on the progression of low-grade intraepithelial lesions to high-grade malignancy. Methods: P۱۶ and ki۶۷ were measured on CIN۱ lesions, and during the average two-year follow-up period, the outcome of positive cases was investigated. A total of ۱۰۶ referred patients between the age of ۱۵ to ۷۵ years were examined from April ۲۰۱۵ to March ۲۰۱۹. Results: Among the patients with progression of CIN۱ to CIN۲ and other severe lesions, p۱۶ was positive in ۱۴ cases (۶۰.۹%), and a significant difference between groups with positive and negative markers in the progression or regression of lesions was noticed. Ki۶۷ frequently occurs in CIN۲ and other severe lesions. Conclusion: The use of p۱۶ and ki۶۷ as predictive markers is still under debate. In countries like the United States, these are not yet used separately for prediction but are being used in combination together. The authors of this study strongly recommend the conduction of further studies to assess the role of p۱۶ in association with other markers and within a larger population so as to apply the functional role of p۱۶ and ki۶۷ in the clinical setting thereby effectively preventing it.