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Results of Acellular Dermis Matrix Graft Used for Tympanoplasty in Guinea Pig Model

محل انتشار: مجله علمی گوش و حلق و بینی ایران، دوره: 27، شماره: 2
سال انتشار: 1394
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 141

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لینک ثابت به این مقاله:
https://civilica.com/doc/1387394

شناسه ملی سند علمی:

JR_IJOTO-27-2_003

تاریخ نمایه سازی: 11 بهمن 1400

چکیده مقاله:

Introduction: To describe the underlay tympanoplasty technique using an acellular dermal graft(AlloDerm) for tympanic membrane (TM) reconstruction in a guinea pig model and to demonstrate the feasibility of the technique using AlloDerm tissue harvested from the prepuce as a source of tissue for future grafting in human TM reconstruction.   Materials and Methods: The prepuce was divided during circumcision and the acellular dermis was prepared using a number of standard processes. Two groups of guinea pigs were prepared. In the case group (۲۰ guinea pigs and ۴۰ ears) removal of TM was performed with tympanoplasty using AlloDerm, and in the control group (eight guinea pigs and ۱۶ ears), removal of TM was performed without tympanoplasty. In each group, the TM was completely removed in one ear and partially removed on the other side, and the integrity of the TMs was re-evaluated after ۸ weeks.   Results: In the case group, the healing rates in the completely and partially removed TMs were ۸۳.۳% and ۹۴.۴%, respectively. The difference in healing rate (۰% and ۶۶.۷%, respectively) was statistically significant (P<۰.۰۵).   Conclusion:  The use of AlloDerm is safe and effective in the repair of TM perforations in a guinea pig model. Acceptable results of AlloDerm tympanoplasty in a guinea pig model may pave the way for the effective use of this material in human TM reconstructions.

کلیدواژه ها:

Partial perforation ، Total perforation ، Tympanoplasty

نویسندگان

Farhad Farahani

Otolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Alireza karimi Yazdi

Otolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Mohammad Ghasemi

Sinus and Surgical Endoscopic Research Center, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Elnaz Shariatpanahi

Department of Otolaryngology, School of Medicine, Hamadan University of Medical Sciences & Health Services, Hamadan, Iran.

Abdol-Mohammad kajbafzadeh

Pediatric Urology Research Center, Children’s Hospital Medical Center, Tehran University of Medical Science, Tehran, Iran.

Saeid Amanpour

Cancer Model Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran.

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