EVALUATION OF THE ROLE OF ANTIBIOTIC USE IN THE DEVELOPMENT OF COW'S MILK PROTEIN ALLERGY WITHIN THE FIRST YEAR OF LIFE AMONG PATIENTS TREATED IN THE NEONATAL INTENSIVE CARE UNIT
محل انتشار: مجله بین المللی کودکان، دوره: 10، شماره: 2
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 141
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شناسه ملی سند علمی:
JR_INJPM-10-2_018
تاریخ نمایه سازی: 30 بهمن 1400
چکیده مقاله:
Introduction: It has been reported that the incidence of cow's milk protein allergy (CMPA) has increased in recent years, especially among infants in the first year of life. It is thought that the use of antibiotics may trigger the development of CMPA by causing intestinal dysbiosis and altering immune response, and thus, it may be a factor responsible for the supposed increase. The relationship between antibiotic use and the development of CMPA has been evaluated in very few studies in the literature. Our aim is to evaluate whether CMPA development is associated with antibiotic use during pregnancy or neonatal period.Method: The development of CMPA within the first year of life among infants hospitalized and followed up in the Neonatal Intensive Care Unit (NICU) of Karabuk University Faculty of Medicine, Training and Research Hospital, between January ۱, ۲۰۱۷ and October ۳۰, ۲۰۲۰, was evaluated.Results: During the study period, ۱۱۲۰ babies were followed up in our NICU. When the data of ۹۷۵ babies who met the inclusion criteria were evaluated, it was found that the use of antenatal and conclusion postnatal antibiotics did not increase the development of CMPA.Conclusion : The data of our study contradicts the two study of which previously associated maternal and infant antibiotic use with the development of CMPA.This contradiction suggests that the aetiology of CMPA is multifactorial and more studies are needed to elucidate the antibiotic-CMPA relationship.
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نویسندگان
Sadrettin Ekmen
Karabük University Faculty of Medicine, Department of Pediatrics, Neonatal Intensive Care Unit, ۷۸۱۰۰, Kılavuzlar/Karabuk. TURKEY
Eylem Sevinc
Karabuk University Medicine Faculty
Hatice Özkul
Karabük University Faculty of Medicine, Department of Family medicine, ۷۸۱۰۰, Kılavuzlar/Karabuk. TURKEY
Turan Derme
Ankara City Hospital Neonatal Intensive Care drturanderme@gmail.com
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