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Calcium dobesilate ameliorates hepatorenal injury induced by carbon tetrachloride in mice

محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 25، شماره: 2
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 195

فایل این مقاله در 7 صفحه با فرمت PDF قابل دریافت می باشد

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لینک ثابت به این مقاله:
https://civilica.com/doc/1403111

شناسه ملی سند علمی:

JR_IJBMS-25-2_002

تاریخ نمایه سازی: 30 بهمن 1400

چکیده مقاله:

Objective(s): Calcium dobesilate (CaD) has anti-oxidant, anti-inflammatory, and anti-apoptotic effects. In this study, the protective effects of CaD against hepatorenal damage induced by carbon tetrachloride (CCl۴) in mice were evaluated. Materials and Methods: Thirty male mice were randomly divided into five groups: Control, CaD ۱۰۰ mg/kg, CCl۴, CCl۴+CaD ۵۰ mg/kg, and CCl۴+CaD ۱۰۰ mg/kg. CaD (۵۰ and ۱۰۰ mg/kg) was administered orally once a day for ۴ weeks. The liver and kidney indices (serum creatinine, blood urine nitrogen, alanine aminotransferase, and aspartate aminotransferase levels) were determined. Also, liver and kidney tissue oxidant/anti-oxidant markers (glutathione peroxidase, malondialdehyde, total anti-oxidant capacity, and superoxide dismutase) were measured. Cleaved caspase-۳, Bax, cytochrome-c, and Bcl-۲ protein levels were measured by immunoblotting method in the liver and kidney tissues. The liver and kidney histopathological changes were evaluated by the Hematoxylin and Eosin (H&E) staining method.Results: CCl۴ induced significant oxidative stress and apoptosis in kidney and liver tissues that was concomitant with histopathological abnormalities in these organs in the CCl۴ group versus the control (P<۰.۰۵). However, CaD (۱۰۰ mg/kg) could significantly improve the histopathological change in the liver and kidney tissues of CCl۴+CaD ۱۰۰ mg/kg mice versus the CCl۴ group (P<۰.۰۵). In addition, CaD (۱۰۰ mg/kg) attenuated the pro and anti-apoptotic markers in the liver and kidney tissues of CCl۴+CaD ۱۰۰ mg/kg mice versus the CCl۴ group (P<۰.۰۵).Conclusion: CaD (۱۰۰ mg/kg) has a protective effect against hepatorenal injury induced by CCl۴ at least via its anti-apoptotic and anti-oxidant properties.

کلیدواژه ها:

Apoptosis ، Calcium dobesilate ، Carbon tetrachloride ، Mice ، Oxidative stress

نویسندگان

Elham Hakimizadeh

Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan,Iran

Ayat Kaeidi

Department of Physiology and Pharmacology, School of medicine. Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Mohammad reza Rahmani

Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Mohammad Allahtavakoli

Department of Physiology and Pharmacology, School of medicine. Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Jalal Hassanshahi

Department of Physiology and Pharmacology, School of medicine. Rafsanjan University of Medical Sciences, Rafsanjan, Iran

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