Blood glucose control in type Ⅰ diabet patients with adequate insulin injection using feedback linearization method

Abstract— In recent decades, the theory of control system has been used in many industrial, medical and other issues. Obtaining an appropriate injection rate of insulin for type ۱ diabetic patients, is always important issue. The goal of controlling and treating diabetes is to keep blood glucose in normal level. In diabetic patients, the glucose regulation system does not perform properly, so it should replace by a control algorithm to regulate blood glucose levels. To develop an effective algorithm, it is essential to know how the glucose regulation system works in a healthy person. In this paper, a minimal Bergman model is used to describe the nonlinear dynamics of the glucose-insulin system for type ۱ diabetes patients. Then, the feedback linearization method is proposed to determine the rate of insulin injection. The results of simulations show that the proposed controller can successfully adjust blood glucose level with proper rate and insulin injection true amount, which confirms the efficiency of the controller and its high accuracy through simulations.