A Systems Biology Approach to Gene Expression Analysis between Triple Negative Breast Cancer and Meta-static Hepatocellular Carcinoma

Objective: Triple negative breast cancer (TNBC) is a type of breast cancer in which estrogen receptor, progesterone receptor, and human epidermal growth factor receptor ۲ (HER-۲) are not expressed. Hepatocellular carcinoma (HCC) is the most com-mon type of primary liver cancer in adults, and is the most com-mon cause of death in people with cirrhosis. Cancer from other organs also may spread to the liver. Other common sites are the lung, and brain. In this study we find the important and common genes that are therapeutic targets in these two diseases. Materials and Methods: Genes related to TNBC and HCC were extracted from Genecard database. Then Common genes of these two diseases were identified by venn diagram. The net-work was constructed by Cytoscape software (version ۳.۵.۱). Then main component of the network was analyzed considering centrality parameters including degree, betweenness, closeness and stress. Furthermore, Gene Ontology (GO) analysis of the key genes was performed.Results: Output of genecards database shown ۴۰۷۶ genes in TNBC and ۷۳۹۲ genes in HCC are differentially expressed. ۲۸۲۸ genes were common between TNBC and HCC. EGFR, MYC, ALB, VEGFA, TNF, MAPK۳, SRC, STAT۳, FN۱, MAPK۱, HRAS, MAPK۸ are the genes with high degree among the genes respectively. ۱۲ crucial genes were analyzed by GO analysis, among all, Biological Process “regulation of macromolecules” (GO:۰۰۱۰۶۰۴), was disclosed as top category followed by Molecular Function”Map activity” (GO:۰۰۰۴۷۰۷). Conclusion: The analysis of common genes of the TNBC and HCC showed that there are some common crucial genes including EGFR, MYC, ALB, VEGFA, TNF, MAPK۳, SRC, STAT۳, FN۱, MAPK۱, HRAS and MAPK۸ which are tightly related to progress of disease. Therefore, these genes and pathways can be considered as an appropriate target for control and treatment of TNBC and HCC.