Synthesis and Study Impaction Antibacterial, Antifungal Activity Newly Pyridazine and ۱,۲,۴-Triazine Derivatives

In this research study, the synthesis sequence of novel pyridazine and ۱,۲,۴-Triazine derivatives was determined by reacting α-hydrazino-N-Carbazole acetamide (۱) with acid anhydride derivatives used glacial acetic acid as a solvent to prepare compounds (۲-۹) pyridazine derivatives reacted compound (۱) with phenyl isocyanate, phenyl thioisocyanate, and α-naphthyl isocyanate to use absolute ethanol as solvent to give compounds (۱۰-۱۲). Compounds (۱۰-۱۲) were condensed with (۲N. NaOH) to give compounds (۱۴-۱۶) to denominate ۱,۲,۴-Triazine derivatives. Reacted compound (۱) with CS۲/KOH used absolute ethanol as solvent to provide potassium salt (۱۳). This salt reacts with ۹۵% hydrazine hydrate to give compound (۱۷). The newly synthesized compounds were tested against different microorganisms to evaluate their antimicrobial activities on bacterial strains, gram-positive bacteria, gram-negative bacteria, and fungal strains to identify the most efficient biologically active compounds.