Antidepressant-like Effects of Intra-cerebroventricular Microinjection of Kaempferol in Male Rats: Involvement of ۵-HT۲ Receptors
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 104
فایل این مقاله در 8 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_AJNPP-9-1_005
تاریخ نمایه سازی: 27 فروردین 1401
چکیده مقاله:
Background and Objective: Kaempferol (KM) is a flavonoid found in plant-derived foods and medicinal plants. Recently, it has been well established that KM plays a protective role against the development of Alzheimer's disease. This study evaluated the effect of intracerebroventricular microinjection of KM on depression and identified the potentially related serotonergic mechanisms in rats.
Materials and Methods: Male rats were assigned to control, vehicle (dimethyl sulfoxide), KM, fluoxetine, cyproheptadine, KM (۲۰ mg/rat) + cyproheptadine (۱ mg/rat), and KM (۲۰ mg/rat) + cyproheptadine (۴ mg/rat) groups. All the groups received their respective treatments for ۳۰ days. Depression was evaluated by both forced swimming and tail suspension tests. Monoamine oxidase-A (MAO-A), as a neurochemical parameter, was also evaluated in the liver and brain of animals.
Results: Treatment with KM significantly decreased immobility time in both forced swimming and tail suspension tests, compared to the vehicle. In the forced swimming test, remarkable effects in immobility time were induced by KM + cyproheptadine after a single dose during weeks ۲, ۳, and ۴ of treatment, compared to the cyproheptadine group. In the tail suspension test, both fluoxetine and KM indicated remarkable effects in the immobility time during weeks ۳ and ۴. In addition, in both the brain and liver, MAO-A activity was decreased after treatment with KM.
Conclusions: These results indicated the antidepressant-like effects of KM through the involvement of ۵HT۲ receptors in male rats.
کلیدواژه ها:
نویسندگان
Mohammad Zarei
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
Saeed Mohammadi
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
Alireza Komaki
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
Zoleikha Golipour Choshali
Endometrium and Endometriosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
مراجع و منابع این مقاله:
لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :