Associated Congenital Heart Anomalies in Children with Cleft Lip and Palate: A Cross Sectional Study
محل انتشار: مجله بین المللی کودکان، دوره: 10، شماره: 4
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 184
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شناسه ملی سند علمی:
JR_INJPM-10-4_005
تاریخ نمایه سازی: 4 اردیبهشت 1401
چکیده مقاله:
Background: Cleft lip and palate has a frequency of ۱ per ۷۰۰ live births, making it among the most prevalent orofacial congenital anomalies of the craniofacial region. Congenital heart disease is the most commonly associated disease with oral cleft. Hence, we have reviewed the association between heart disease and cleft lip and/or palate in the pediatric population.Methods: In this cross-sectional study, the patients with oral clefts referring to the hospitals affiliated with the Mashhad University of Medical Sciences during ۲۰۱۵ to ۲۰۱۶ were evaluated. Demographic, clinical, and echocardiographic data were collected and analyzed statistically.Results: One hundred twenty two patients with cleft lip and/or palate underwent echocardiography (۴۹.۲% males, ۵۰.۸% females). Based on Z-score outcomes, most of the patients with scores above zero had isolated cleft palate (۶۳.۶%). Patients with Z-scores of ۰ to -۱.۳ and lower than -۱.۳ mostly had both cleft lip and palate (۶۱.۳%) or isolated cleft palate (۵۵.۵%), and these differences were significant (p=۰.۰۱۰). Furthermore, the frequency of the patients with Z-scores lower than zero was significantly higher in cleft lip and palate cases with congenital heart disease compared to non-congenital heart disease cases (۴۳ vs. ۱۹; p=۰.۰۰۲). The patients with pathologic symptoms in the physical examination were mainly diagnosed as abnormal based on their echocardiography (۷۱.۲%), and those without these symptoms were mainly diagnosed as normal based on their echocardiography (۵۹.۲%) with significant differences (p=۰.۰۰۱).Conclusions: No significant difference was observed regarding the distribution of different types of congenital heart disease between the different types of cleft lip and/or palate.
کلیدواژه ها:
نویسندگان
Hassan Mottaghi Moghaddam shahri
Pediatric department, Faculty of medicine, Mashhad University of medical sciences, Mashhad, Iran
Mohsen Farzaneh
Pediatric department, Faculty of medicine, Mashhad University of medical sciences, Mashhad, Iran
Alireza Chamani
Assistant Professor of Orthodontics Department of Orthodontics, School of Dentistry Zahedan University of Medical Sciences
Arezoo Jahanbin
Department of Orthodontics, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
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