Evaluation of lipid factors and coagulation pathway in the prognosis of heart disease in people with type ۲ diabetes

Diabetes is often associated with undiagnosed dyslipidemia. This disease is caused by insufficient insulin secretion, insulin resistance, increased hepatic glucose production, and impaired fat metabolism. The most common cause of ischemia and infarction is coronary artery atherosclerosis, in which diabetes mellitus plays a very important role along with other major and minor atherogenic factors. The aim of this study was to investigate the clinical relationship between coagulation pathway and lipid profile as biochemical models predicting heart disease for glycemic control in patients with type ۲ diabetes mellitus (T۲DM).In this study, ۴۵ patients with type ۲ diabetes with acute myocardial infarction, ۴۵ patients with type II diabetes and ۴۵ healthy individuals without any acute or chronic disorders were compared.This study showed that people with type II diabetes with acute myocardial infarction showed a significant increase in some coagulation factors, biochemical factor and LDL compared to people with type II diabetes (without myocardial infarction). Also factors such as HDL, PLT and PT in people with Type II diabetes who experienced a heart attack was significantly lower than people with type II diabetes who did not experience a heart attack. Lipid (LDL-C) and fat ratio (LDL-C / HDL-C and TC / HDL-C ratios) and coagulation pathway factors indicate potential markers that can be used to predict glycemic control and heart disease. Used in patients with type ۲ diabetes. However, more studies are needed in this area.