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مقالات فارسیISIکنفرانسهاژورنالها

Anticandidosic Activity and Acute Toxicity of Quercus Suber L. Bark Extracts

محل انتشار: مجله علوم دارویی و شیمی، دوره: 5، شماره: 5
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 165

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لینک ثابت به این مقاله:
https://civilica.com/doc/1440647

شناسه ملی سند علمی:

JR_JMCH-5-5_011

تاریخ نمایه سازی: 17 اردیبهشت 1401

چکیده مقاله:

The cork oak (Quercus suber L.) is commonly used in traditional pharmacopoeia. The main objective of this work is to contribute to the valorization of this plant species through the study of the anticandidosic activity of cork oak (Quercus suber) bark extracts stemming from decoction, maceration and Soxhlet methods of extraction. The anticandidosic potential of the elaborated extracts was tested on five different Candida albicans strains. Our results showed that all tested extracts tested displayed an inhibitive activity against the five strains.  The study of the acute toxicity showed that the lethal dose is ۱۱۵۰ mg/kg in mice, which remained moderately toxic according to Hodge and Sterner classification scale. Taken together, these results underline the antifungal potential of cork oak bark extracts against Candida albicans strains, suggesting a prospective use of these extracts for candidiasis treatment.

کلیدواژه ها:

Acute toxicity ، anticandidosic ، Quercus suber L

نویسندگان

Qamar Lahlimi-Alami

Laboratory of Plant Biotechnology and Physiology, Center for Plant and Microbial Biotechnology, Biodiversity and Environment, Faculty of Sciences, Mohammed V University in Rabat, Rabat, Morocco

Rajaa Layachi

Laboratory of Plant Biotechnology and Physiology, Center for Plant and Microbial Biotechnology, Biodiversity and Environment, Faculty of Sciences, Mohammed V University in Rabat, Rabat, Morocco

Rachida Hassikou

Botany and Valorization of Plant Resources Team, Plant and Microbial Biotechnology, Biodiversity and Environment Research Center, Faculty of Sciences, Mohammed V University in Rabat, Rabat, Morocco

Jalila Benjelloun

Laboratory of Plant Biotechnology and Physiology, Center for Plant and Microbial Biotechnology, Biodiversity and Environment, Faculty of Sciences, Mohammed V University in Rabat, Rabat, Morocco

Lamiae Amallah

Botany and Valorization of Plant Resources Team, Plant and Microbial Biotechnology, Biodiversity and Environment Research Center, Faculty of Sciences, Mohammed V University in Rabat, Rabat, Morocco

Naima Guennoun

Botany and Valorization of Plant Resources Team, Plant and Microbial Biotechnology, Biodiversity and Environment Research Center, Faculty of Sciences, Mohammed V University in Rabat, Rabat, Morocco

Younes Zaid

Botany and Valorization of Plant Resources Team, Plant and Microbial Biotechnology, Biodiversity and Environment Research Center, Faculty of Sciences, Mohammed V University in Rabat, Rabat, Morocco

Sarah Bouzroud

Laboratory of Plant Biotechnology and Physiology, Center for Plant and Microbial Biotechnology, Biodiversity and Environment, Faculty of Sciences, Mohammed V University in Rabat, Rabat, Morocco

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