Wound Healing Effect of Hydroalcoholic Extract of Salvadora Persica (Miswak) on Physicaly Induced Second-Degree Burn Wound in BALB/c Mice
سال انتشار: 1400
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 286
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شناسه ملی سند علمی:
CONFMT05_048
تاریخ نمایه سازی: 21 اردیبهشت 1401
چکیده مقاله:
Introduction: Different Scholars have mentioned a lot of benefits for Salvadora Persica(SP) compounds. The Present study was conducted aiming at evaluating the effect of hydroalcoholic extract of SP on second-degree burn healing in Mice.Materials and Methods: The present study population was ۶۰ mature mice (BALB/c). The mice were divided into ۵ equal groups. Groups ۱ and ۲ were treated by means of the application of ۵% hydroalcoholic extract of SP and ۱۰% extract of it, respectively; regarding group ۳ revieved silver sulfadiazine ointment. Group ۴ was treated using Vaseline. Group ۵ received no treatment. Then, samples from the injured sites was gathered, and wound healing was evaluated histopathologically.Results: Inflammation and infilteration of nutrophils and lymphocytes in the treatment groups, i.e. the groups to which ۵% and ۱۰% SP extract was applied, demonstrated a significant decrease, compared to the vaseline and sham groups (P<۰.۰۱). Moreover, the number of fibroblasts increased followed by collagen production, epithelialization and new hair follicles formation at the wound margins on the ۱۰th and ۱۴th day in the ۵% and ۱۰% SP extract groups significantly increased compared to vaseline and sham groups (P<۰.۰۵). The number of fibroblasts and the density of collagen tissues in the group treated with ۱۰% SP extract even showed a significant increase compared to the groups treated with ۵% SP extract and silver sulfadiazine on the ۱۴th day.Conclusion: It was found that hydroalcoholic salvadora Persica extract accelerated the healing of second-degree burn injuries in BALB/c mice.
کلیدواژه ها:
نویسندگان
Hamed Lotfi
Department of Medical Science, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
Mohammad Afshar
Department of Anatomical Sciences, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
Mohammad Afshar
Medical Toxicology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mohammad Mehdi Hassanzadeh Taheri
Department of Anatomical Sciences, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
Mahmoud Zardast
Department of Pathology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran