Extremely low frequency electromagnetic fields alter expression of C-Myc in gastric cancer cell line

Biological effects of electromagnetic fields (EMF), in particular their beneficial or adverse effects on the promotion and progression of cancer, have attracted considerable attention. C-Myc has an important regulatory role in cell transformation and causes metabolic changes that accompany malignant transformation. In this study, changes in the expression of c-Myc in the gastric cancer cell line (AGS) following the exposure to extremely low-frequency magnetic fields (ELF-MF) were investigated. AGS cells were exposed to ELF-MF with magnetic flux densities of ۰. ۲۵, ۰.۵, ۱, and ۲ mT for ۱۸ h, discontinuously (۲h on/ ۲h off). To evaluate the expression changes of c-Myc real-time PCR was used. The results showed that discontinuous magnetic fields could reduce c-Myc expression. The difference in the results of c-Myc under the influence of magnetic fields may be described by the hypothesis of the window effect of the fields. Our results indicated that ELF-MFs can induce changes in c-Myc expression