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Assessment of the Wound Healing Property of Aqueous Extract of Stevia Rebaudiana: an Ethnomedicinal Plant

محل انتشار: دوفصلنامه بیوتکنولوژی گیاهی، دوره: 3، شماره: 1
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 129

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لینک ثابت به این مقاله:
https://civilica.com/doc/1455907

شناسه ملی سند علمی:

JR_PBP-3-1_002

تاریخ نمایه سازی: 10 خرداد 1401

چکیده مقاله:

Ethnomedicinal plants are considered as the recent resources for producing components to healt wounds. Stevia rebaudiana is a native plant in Iran, which has been used as an anti-inammatory, antioxidant, antibacterial, antifungal, antiparasitic, antiviral, and antidiabetic agent. In this study, the authors describe the property of aqueous extract of S. rebaudiana on wound healing markers in Sprague-Dawley male rats. Full-thickness excisional wounds (۲×۲ cm) was induced on the back of ۳۲ rats. In this study, rats were randomly divided into four main groups (n=۸), untreated (control) and treated with ۱ml basal cream, ۱ml tetracycline (۳%), and ۱ml S. rebaudiana aqueous extract ۱۰% for ۱۰ days. Animals of each group were euthanized at ۱۰ days post-injury (DPI) and wounds were assessed through gross and histopathological analyses. Treated animals with S. rebaudiana demonstrated a considerable decrease in the wound area during the experiment compared to control, basal cream, and tetracycline groups. Parameters such as healing tissue alignment and epithelialization indicated substantial changes when compared to other groups. Moreover, treatment with S. rebaudiana decreased the number of wound surface area, lymphocytes, and macrophages, it increased the number of blood vessels and fibrocytes compared to other groups at ۱۰ days. Thus, the present research shows the wound healing effect of the S. rebaudiana, suggesting to be used as a therapeutic supplement. Additional in vivo researches and clinical trials would be needed to justify the findings.  

کلیدواژه ها:

Stevia rebaudiana ، extract ، wound healing property ، rat.

نویسندگان

Naser Abbasi

Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran

Hori ghaneialvar

Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, IranDepartment of Clinical Biochemistry, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran

Sania Saneei

Department of Dermatology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

Mohammad Mahdi zangeneh

Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran

akram zangeneh

Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran

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