Serum Levels of Interleukin-۱۰ as a Potential Indicator of Outcome in Premature Neonates with Respiratory Distress Syndrome

سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 157

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شناسه ملی سند علمی:

JR_IRJN-13-2_015

تاریخ نمایه سازی: 21 خرداد 1401

چکیده مقاله:

Background: Respiratory distress syndrome (RDS) is one of the major causes of mortality in preterm newborns. Regarding the close association between inflammatory pathways and the occurrence of RDS, the present study aimed to determine the serum level of interleukin-۱۰ (IL-۱۰) in premature neonates with and without RDS. Methods: In this case-control study, the serum level of IL-۱۰ was assessed by immunoassay method in both groups of ۳۰ premature neonates with RDS and ۲۸ newborns without RDS as controls. Statistical analysis was conducted to compare potential variations among premature neonates with or without RDS. Results: The mean level of IL-۱۰ was significantly higher in neonates with RDS, compared to the non-RDS group (۴۱.۲۰±۷۵.۷۸ pg/ml versus ۷.۷۳±۱۴.۳۱ pg/ml, P=۰.۰۱۴, respectively). The IL-۱۰ was significantly higher in non-survived neonates, compared to survived newborns (۱۷۸.۷۶±۶۹.۶۷ pg/ml vs. ۶.۸۱±۴.۰۶ pg/ml, P=۰.۰۰۰۱). In multivariate linear regression analysis, the presence of RDS was associated with the increased level of serum IL-۱۰ (Beta=۱.۰۳۸, P=۰.۰۰۱). Conclusion: This study revealed that the increased serum levels of IL-۱۰ in premature neonates with RDS might be considered an early indicator of fatal outcomes with high specificity.    

نویسندگان

Seyedeh Zohreh Jalali

Department of Paediatric, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran Pediatric Diseases Research Center, Guilan University of medical sciences, Rasht, Iran

Fatemeh Yousefi

Department of Paediatric, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran Pediatric Diseases Research Center, Guilan University of medical sciences, Rasht, Iran

Farshid Saadat

Department of Immunology, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran

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