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A Prospective Study of Neonates with Persistent Pulmonary Hypertension of the Newborn: Prevalence, Clinical Outcomes, and Risk Factors

محل انتشار: مجله علمی ناباروری ایران، دوره: 13، شماره: 2
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 105

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لینک ثابت به این مقاله:
https://civilica.com/doc/1461333

شناسه ملی سند علمی:

JR_IRJN-13-2_016

تاریخ نمایه سازی: 21 خرداد 1401

چکیده مقاله:

Background: Persistent pulmonary hypertension of the newborn (PPHN) is caused by the inability of the pulmonary arteries to dilate at birth, which leads to severe hypoxemia. Several risk factors have been identified in association with its occurrence and prognosis. The present study aimed to determine the incidence of PPHN, describe neonates’ characteristics, and evaluate the etiology, as well as mortality risk factors in newborns hospitalized due to PPHN at Bahrami Children’s Hospital, Tehran, Iran, from ۲۰۱۷ to ۲۰۲۰. Methods: A total of ۴۹ neonates were included in the present study. The PPHN diagnosis was based on clinical criteria and echocardiography provided by neonatologists. Therefore, a complete history, physical examination, and laboratory data were gathered. Afterward, PPHN etiology was determined, and the patients were followed up for six months. Finally, PPHN prevalence was calculated and probable risk factors for its complications were investigated by using logistic regression analysis. Results: The findings revealed that the prevalence of PPHN was ۳.۵% in the center under study, and the mortality rate, as well as complete recovery, were ۲۴.۵% and ۶۳%, respectively. It was also found that factors, such as male gender, abnormal Apgar score at birth, and cesarean delivery, were high in a percentage of PPHN patients; however, they were not associated with PPHN mortality and morbidity. The only variable that had a significant association with mortality and morbidity was an abnormal white blood cell count. Conclusion: The need for inotropic support was associated with poor outcomes. From the aspect of etiology, there exists higher mortality rates, complications, and poor prognosis among PPHN patients with underdevelopment, compared to the ones with maldevelopment.    

کلیدواژه ها:

Developmental disorder ، Mortality ، Persistent pulmonary hypertension of the newborn ، PPHN ، Prevalence ، Risk Factor

نویسندگان

Mahbod Kaveh

Department of Pediatric Neonatology, Bahrami Children’s Hospital, Tehran University of Medical Sciences, Tehran, Iran

Amir Ali Mahboobipour

School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Ali Bitaraf

School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

Maryam Shojaei

School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Behzad Mohammadpour Ahranjani

Department of Pediatric Cardiology, Bahrami Children’s Hospital, Tehran University of Medical Sciences, Tehran, Iran

Baharak Majidi-Nejad

School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Mohammad Kaji Yazdi

Department of Pediatric Hematology and Oncology, Bahrami Children’s Hospital, Tehran University of Medical Sciences, Tehran, Iran

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