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مقالات فارسیISIکنفرانسهاژورنالها

Synthesis, physicochemical characterization and pharmaceutical function of niosomal nanoparticles-encapsulated bioactive compound for osteosarcoma treatment

محل انتشار: مجله علوم نانو، دوره: 9، شماره: 3
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 210

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لینک ثابت به این مقاله:
https://civilica.com/doc/1472735

شناسه ملی سند علمی:

JR_NAMJ-9-3_003

تاریخ نمایه سازی: 4 تیر 1401

چکیده مقاله:

Objective(s): The purpose of this study is to synthesizing and characterizing niosomes containing curcumin in order to delivery to bone cancer cells. Nano-carriers were synthesized using thin film method and curcumin was loaded into them by active hydration method.Materials and Methods: The optimal formula was selected based on the encapsulation efficiency and release profile. Then the physicochemical properties of nanoparticles such as size and zeta potential, morphology and system-drug interaction were evaluated by using DLS, SEM, AFM and FTIR methods. Finally, the toxicity of nanosystems on bone cancer cell line MG-۶۳ as resistant cells to treatment was examined by MTT assay. Results: Niosomes containing curcumin with size of ۹۰.۸ nm, PDI of ۰.۲۳۶, zeta potential of -۸.۹ and encapsulation rate of ۷۳.۵ ± ۱.۸ have slow-release profile. The maximum release rate of the drug for this nano-carrier in healthy and cancerous within ۷۲ hr was ۶۰.۱۲% and ۶۴.۳۵% respectively. IR and morphological investigations showed no chemical interaction between curcumin and nanocarrier and the particles are spherical in shape. The results of the MTT assay also showed that by encapsulating curcumin, its effect on bone cancer cells increased and the resistance of MG-۶۳ cells to treatment decreased. Conclusion: The results of this study showed that niosomes containing curcumin with appropriate physicochemical properties can improve the treatment process in bone cancer cells and also reduce the resistance of this cell to the drug and could be proposed as a new therapeutic strategy to help the treatment of osteosarcoma.

کلیدواژه ها:

Bioactive compound ، Curcumin ، MG-۶۳ cells ، Niosomal nanoparticles ، Osteosarcoma

نویسندگان

Mohammad Taebpour

Depatment of Medical Biotechnology, Faculty of Medicine, Shahid Sadoughi University of Medical sciences, Yazd, Iran

Milad Akhlaghi

Department of Clinical Biochemistry, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Shayesteh Shahriyari

Department of Medical Biotechnology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Saeedeh Hajihosseini

Department of Mechanical Engineering, University of Tehran, Tehran, Iran

Bibi Fatemeh Haghiralsadat

Depatment of Medical Biotechnology, Faculty of Medicine, Shahid Sadoughi University of Medical sciences, Yazd, Iran

Fatemeh Oroojalian

Department of Advanced Technologies, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran

Davood Tofighi

Department of Psychology, University of New Mexico, Albuquerque, New Mexico, USA

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  • Durfee RA, Mohammed M, Luu HH. Review of osteosarcoma and ...
  • Harrison DJ, Geller DS, Gill JD, Lewis VO, Gorlick R. ...
  • Czarnecka AM, Synoradzki K, Firlej W, Bartnik E, Sobczuk P, ...
  • Isakoff MS, Bielack SS, Meltzer P, Gorlick R. Osteosarcoma: current ...
  • Simpson S, Dunning MD, de Brot S, Grau-Roma L, Mongan ...
  • Smrke A, Anderson PM, Gulia A, Gennatas S, Huang PH, ...
  • Omidi M, Malakoutian M, Choolaei M, Oroojalian F, Haghiralsadat F, ...
  • Zhang Y, Yang J, Zhao N, Wang C, Kamar S, ...
  • Li S, Sun W, Wang H, Zuo D, Hua Y, ...
  • Spínola V, Castilho PC. Evaluation of Asteraceae herbal extracts in ...
  • Jiang Y, Peng T, Gaur U, Silva M, Little P, ...
  • Sivaraman D, Anbu N, Kabilan N, Kumar MP, Shanmugapriya P, ...
  • Mansoori B, Mohammadi A, Doustvandi MA, Mohammadnejad F, Kamari F, ...
  • Akhlaghi M, Ebrahimpour M, Ansari K, Parnian F, Zarezadeh Mehrizi ...
  • Babazadeh A, Zeinali M, Hamishehkar H. Nano-phytosome: a developing platform ...
  • Hewlings SJ, Kalman DS. Curcumin: a review of its effects ...
  • Nelson KM, Dahlin JL, Bisson J, Graham J, Pauli GF, ...
  • Hussain Z, Thu HE, Amjad MW, Hussain F, Ahmed TA, ...
  • Fadus MC, Lau C, Bikhchandani J, Lynch HT. Curcumin: An ...
  • da Silva AC, de Freitas Santos PD, do Prado Silva ...
  • Zhang W, Chen C, Shi H, Yang M, Liu Y, ...
  • Rahmani AH, Alsahli MA, Aly SM, Khan MA, Aldebasi YH. ...
  • Salehi B, Stojanović-Radić Z, Matejić J, Sharifi-Rad M, Kumar NVA, ...
  • Oroojalian F, Rezayan AH, Shier WT, Abnous K, Ramezani M. ...
  • Rashidi A, Omidi M, Choolaei M, Nazarzadeh M, Yadegari A, ...
  • Rahimizadeh M, Eshghi H, Shiri A, Ghadamyari Z, Matin MM, ...
  • Akhlaghi M, Taebpour M, Lotfabadi NN, Naghib SM, Jalili N, ...
  • Mohseni M, Dehghani AM, Akhlaghi M, Ansari K. A New ...
  • Hemati M, Haghiralsadat F, Jafary F, Moosavizadeh S, Moradi A. ...
  • Nia AH, Behnam B, Taghavi S, Oroojalian F, Eshghi H, ...
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  • Ferrari S, Smeland S, Mercuri M, Bertoni F, Longhi A, ...
  • Chen P, Wang H, Yang F, Chen H, He W, ...
  • Zhang Y, Chen P, Hong H, Wang L, Zhou Y, ...
  • Aziz MNM, Hussin Y, Che Rahim NF, Nordin N, Mohamad ...
  • Yu D, An F, He X, Cao X. Curcumin inhibits ...
  • Luo Z, Li D, Luo X, Li L, Gu S, ...
  • Honary S, Zahir F. Effect of zeta potential on the ...
  • Danhier F, Feron O, Préat V. To exploit the tumor ...
  • Malekimusavi H, Ghaemi A, Masoudi G, Chogan F, Rashedi H, ...
  • Ghafari M, Haghiralsadat F, Khanamani Falahati‐pour S, Zavar Reza J. ...
  • Akhlaghi M, Taebpour M, Sharafaldini M, Javani O, Haghiralsadat BF, ...
  • Azadmanesh F, Pourmadadi M, Zavar Reza J, Yazdian F, Omidi ...
  • Mirhosseini M, Shekari-Far A, Hakimian F, Haghiralsadat BF, Fatemi SK, ...
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