Comparison of aspirin renogram and captopril renogram in the diagnosis of renovascular hypertension

Renal artery stenosis (RAS) is the most common cause of secondary hypertension. Preliminary data indicate that aspirin renography with hippurate may be more sensitive for detection RAS. In this study ۲۰ patients with known or suspected RAS underwent aspirin renography (۲۰ mg/kg orally ۱ hour before injection of radiotracer) and captopril renography (۵۰ mg orally) with ۹۹mTc-DTPA. Renal angiography was performed in all patients. Of the ۲۰ patients enrolled, ۱۱ had unilateral RAS on angiography. Captopril renography was positive in ۱۰ patients (۹۱% sensitivity and ۹۰% specificity). Aspirin renogram showed ۹ patients with RAS correctly (۸۱.۸% sensitivity and ۱۰۰% specificity). Our data suggest that aspirin renography with ۹۹mTc-DTPA has comparable sensitivity with captopril in detection of unilateral RAS.