Antiphospholpid Syndrome: Risk Factor for Preeclampsia

Antiphospholipid syndrome is the most frequently acquired risk factor for a treatable cause of recurrent abortion, stillbirth, preeclampsia, intrauterine death, premature birth, and fetal growth restriction. The purpose of this study was to review current literature about the antiphospholipid syndrome as a risk factor for preeclampsia. Systematic literature searches using pre-specified terms were performed on PubMed, Ovid EMBASE, Ovid Medline, Cochrane library, Clinicaltrials.gov, and Web of Science from database inception dates to Jun ۲۰۲۲. Antiphospholipid syndrome, in relation to pregnancy, is characterized by the presence of antiphospholipid autoantibodies in association with repeated fetal loss and complications such as preeclampsia retarded fetal growth, or placental insufficiency.