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مقالات فارسیISIکنفرانسهاژورنالها

Increased circulating platelet and endothelial-derived microparticles in patients with cardiac syndrome X

محل انتشار: مجله آریا آترواسکلروز، دوره: 17، شماره: 1
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 105

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استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1504180

شناسه ملی سند علمی:

JR_RYA-17-1_005

تاریخ نمایه سازی: 2 شهریور 1401

چکیده مقاله:

BACKGROUND: Cardiac syndrome X (CSX) has been associated with endothelial dysfunction and inflammation. We conducted a case-control study to evaluate the association between platelet‎ and endothelial-derived microparticles (PMPs and EMPs), as specific quantitative plasma markers of endothelial dysfunction, and the presence of CSX.METHODS: The present study was conducted on ۴۰ CSX patients and ۱۹ healthy individuals. C-reactive protein (CRP), and hematological and biochemical parameters were evaluated. The MP concentration in platelet-poor plasma (PPP) was quantitatively determined through flow cytometry using specific anti-human CD۳۱, CD۴۱a, CD۶۲E, and CD۱۴۴antibodies.RESULTS: The mean platelet volume (MPV) and positive CRP rate (≥ ۳.۸ mg/l) were higher in patients compared to controls (P = ۰.۰۲۰ and P = ۰.۰۱۰, respectively). The CD۶۲E+, CD۱۴۴+, and CD۳۱+۴۱− EMPs, as well as CD۴۱+ and CD۳۱+CD۴۱+ PMPs showed significant increase in CSX patients compared to controls (P < ۰.۰۵۰). There were direct correlations between the mean percentage of detected EMPs and PMPs as well as between their expression intensity; however, a reverse correlation was seen between the percentage of MPs and CD۱۴۴and CD۴۱. Moreover, the MP level was reversely associated with prothrombin time (PT) and partial thromboplastin time (PTT) values. Only CD۳۱+CD۴۱+ PMP was correlated with CRP.CONCLUSION: It seems that EMPs and PMPs increase in CSX, which may contribute to various processes involved in the development of this syndrome.

کلیدواژه ها:

Cardiac Syndrome X ، Endothelium ، Dysfunction ، Inflammation ، Microparticles

نویسندگان

Fereshteh Ghaffari

Department of Biochemistry, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran

Yousef Rasmi

Professor, Cellular and Molecular Research Center AND Department of Biochemistry, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran

Mir Hossein Seyed Mohammadzad

Associate Professor, Department of Cardiology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran

Shahram Seyedi

Assistant Professor, Department of Immunology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran

Alireza Shirpoor

Professor, Department of Physiology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran

Elmira Roshani-Asl

Department of Biochemistry, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran

Ehsan Saboory

Professor, Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran

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