ورود
مقالات فارسیISIکنفرانسهاژورنالها

Polymorphisms of LPA gene, rs۱۸۰۱۶۹۳ and rs۷۷۶۵۷۸۱, are not associated with premature myocardial infarction in the Iranian population

محل انتشار: مجله آریا آترواسکلروز، دوره: 17، شماره: 1
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 171

فایل این مقاله در 8 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1504206

شناسه ملی سند علمی:

JR_RYA-17-1_031

تاریخ نمایه سازی: 2 شهریور 1401

چکیده مقاله:

BACKGROUND: Myocardial infarction (MI) is one of the leading causes of mortality globally. Although it is most prevalent in the elderly, it may occur in young adults (men ≤ ۵۵ years or women ≤ ۶۵ years) as premature MI (PMI). As awareness of genetic risks may lead to effective prevention of PMI, we aim to investigate the association of two susceptible single nucleotide polymorphisms (SNPs) in the LPA gene with PMI in the Iranian population, rs۱۸۰۱۶۹۳ and rs۷۷۶۵۷۸۱, identified in previous genome-wide association studies (GWAS).METHODS: A total number of ۸۵ patients with PMI and ۸۵ healthy controls were recruited from December ۲۰۱۵ to March ۲۰۱۶ from Isfahan, Iran. Peripheral blood samples were collected from all individuals. Deoxyribonucleic acid (DNA) was extracted and genotyped at rs۱۱۸۱۶۹۳ and rs۷۷۶۵۷۸۱ polymorphisms, using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results were statistically analyzed to find any possible association of the two polymorphisms with PMI by SPSS software and P-values less than ۰.۰۵ were considered to be statistically significant.RESULTS: Statistical analysis displayed no significant difference between rs۱۸۰۱۶۹۳ (P = ۰.۸۱۵)/rs۷۷۶۵۷۸۱ (P = ۰.۷۴۶) alleles in patients with PMI and healthy control subjects.CONCLUSION: There is no meaningful association between rs۱۸۰۱۶۹۳/rs۷۷۶۵۷۸۱ and PMI incidence in the Iranian population.

کلیدواژه ها:

Apolipoproteins ، Myocardial Infarction ، Single Nucleotide Polymorphism

نویسندگان

Mahsa Rahimi

Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Hossein Khanahmad

Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Mojgan Gharipour

Department of Genetics and Epigenetics, Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Hamidreza Roohafza

Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Minoo Dianatkhah

Heart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Elham Khosravi

Interventional Cardiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Ladan Sadeghian

Department of Genetics and Epigenetics, Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Masoumeh Sadeghi

Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

مراجع و منابع این مقاله:

لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :
  • World Health Organization. Noncommunicable diseases country profiles ۲۰۱۸ [Online]. [cited ...
  • Dugani SB, Murad W, Damilig K, Atos J, Mohamed E, ...
  • Pineda J, Marin F, Roldan V, Valencia J, Marco P, ...
  • Hbejan K. Smoking effect on ischemic heart disease in young ...
  • Kazemi T, Sharifzadeh GR, Zarban A, Fesharakinia A, Rezvani MR, ...
  • Ranthe MF, Petersen JA, Bundgaard H, Wohlfahrt J, Melbye M, ...
  • Shah N, Kelly AM, Cox N, Wong C, Soon K. ...
  • Dehghan A, Bis JC, White CC, Smith AV, Morrison AC, ...
  • Kathiresan S, Voight BF, Purcell S, Musunuru K, Ardissino D, ...
  • Peden JF, Hopewell JC, Saleheen D, Chambers JC, Hager J, ...
  • Schunkert H, Konig IR, Kathiresan S, Reilly MP, Assimes TL, ...
  • Tregouet DA, Konig IR, Erdmann J, Munteanu A, Braund PS, ...
  • Cai G, Huang Z, Zhang B, Yu L, Li L. ...
  • Song ZK, Wu HD, Cao HY, Qin L. The association ...
  • Song ZK, Cao HY, Wu HD, Zhou LT, Qin L. ...
  • Kamstrup PR, Tybjaerg-Hansen A, Steffensen R, Nordestgaard BG. Genetically elevated ...
  • Erqou S, Kaptoge S, Perry PL, Di Angelantonio E, Thompson ...
  • Enas EA, Varkey B, Dharmarajan TS, Pare G, Bahl VK. ...
  • Clarke R, Peden JF, Hopewell JC, Kyriakou T, Goel A, ...
  • Koch W, Mueller JC, Schrempf M, Wolferstetter H, Kirchhofer J, ...
  • Suguna S, Nandal DH, Kamble S, Bharatha A, Kunkulol R. ...
  • Dugani SB, Ayala Melendez AP, Reka R, Hydoub YM, McCafferty ...
  • Kazemi T, Sharifzadeh G, Zarban A, Fesharakinia A. Comparison of ...
  • Zera E, Zaimi E, Metalla M, Prifti S, Zera E. ...
  • Xu S, Cheng J, Li NH, Chen YN, Cai MY, ...
  • Dong C, Fu Z, Wang B, Zhu Q, Cha E, ...
  • Rouhani B, Ghaderian SMH, Salehi Z. Investigation of LPA sequence ...
  • Mirhafez SR, Avan A, Khatamianfar S, Ghasemi F, Moohebati M, ...
  • Ahani M, Ghaderin SMH, Azargashb E, Hasanzad M. Lack of ...
  • Dai W, Long J, Cheng Y, Chen Y, Zhao S. ...
  • Azarfarin R, Dashti M, Totonchi Z, Ziyaeifard M, Mehrabanian M, ...
  • Kazemi T, Sharifzadeh Ghr, Zarban A, Fesharakinia Azit. Lipoprotein (A) ...
  • Mirzaei M, Rahnama A, Esmaeiliyan F, Bakhshi H. Serum level ...
  • Yousefi AA, Givtaj N, Zavareh A, Sabourizadeh N, Chizaree MR. ...
  • Rezvan H, Rahimi F, Darvish H. Lipoprotein (A)levels and coronary ...
  • Khera AV, Everett BM, Caulfield MP, Hantash FM, Wohlgemuth J, ...
  • Nestel PJ, Barnes EH, Tonkin AM, Simes J, Fournier M, ...
  • Albers JJ, Slee A, O'Brien KD, Robinson JG, Kashyap ML, ...
  • Patel AP, Wang () M, Pirruccello JP, Ellinor PT, Ng ...
  • Guddeti RR, Patil S, Ahmed A, Sharma A, Aboeata A, ...
  • Marcovina SM, Koschinsky ML. Evaluation of lipoprotein(a) as a prothrombotic ...
  • Vavuranakis MA, Jones SR, Cardoso R, Gerstenblith G, Leucker TM. ...
  • Dai X, Wiernek S, Evans JP, Runge MS. Genetics of ...
    • نمایش کامل مراجع