ورود
مقالات فارسیISIکنفرانسهاژورنالها

Resistin and prooxidant-antioxidant balance: Markers to discriminate acute coronary syndrome from stable angina

محل انتشار: مجله آریا آترواسکلروز، دوره: 16، شماره: 2
سال انتشار: 1399
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 155

فایل این مقاله در 9 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1504316

شناسه ملی سند علمی:

JR_RYA-16-2_001

تاریخ نمایه سازی: 2 شهریور 1401

چکیده مقاله:

BACKGROUND: Resistin and oxidative stress may play a role in the pathogenesis of coronary heart disease (CHD) including acute coronary syndrome (ACS). The aim of this study was to investigate the role of serum resistin and prooxidant-antioxidant balance (PAB) in ACS occurrence in order to differentiate it from stable angina. Moreover, we aimed to determine the correlation between resistin and PAB in patients with ACS and its difference from patients with stable CHD.METHODS: This cross-sectional, descriptive study was conducted on ۵۰ patients with ACS and ۵۰ patients with stable CHD who underwent coronary angiography (CAG). Serum resistin level was measured using enzyme-linked immunosorbent assay (ELISA). PAB and other variables were analyzed using standard methods.RESULTS: A significant increase in serum resistin and PAB was observed in patients with ACS (۲.۵۵ ± ۰.۱۳ ng/ml and ۱۲۳.۵ ± ۵.۵۸ HK unit, respectively) compared to patients with stable CHD (۱.۵۳ ± ۰.۱۲ ng/ml and ۹۵.۹ ± ۲.۷ HK unit, respectively) (P < ۰.۰۰۱). In addition, a significant positive correlation was seen between serum resistin and PAB in patients with ACS (r = ۰.۳۹; P = ۰.۰۰۵), but this correlation was not found in patients with stable CHD (r = ۰.۲۱; P = ۰.۱۴۰). Resistin (r = ۰.۵۲; P < ۰.۰۰۱) and PAB (r = ۰.۵۵; P < ۰.۰۰۱) were significantly associated with high-sensitivity C-reactive protein (hs-CRP) in patients with ACS, but this association was not found in patients with stable CHD (resistin: r = ۰.۲۴; P = ۰.۰۹۰; PAB: r = -۰.۰۲: P = ۰.۹۱۰).CONCLUSION: High serum resistin or PAB levels, and their association with the occurrence of ACS, can be used as a robust discriminating factor to differentiate ACS from stable CHD. 

کلیدواژه ها:

Acute Coronary Syndrome ، Resistin ، Antioxidants

نویسندگان

Ali Pourmoghaddas

Interventional Cardiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Armin Elahifar

Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Faramarz Darabi

Heart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Ahmad Movahedian

Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences AND Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Afshin Amirpour

Assistant Professor, Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Nizal Sarrafzadegan

۲- Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran ۶- Faculty of Medicine, School of Population and Public Health, University of British Columbia, Vancouver,

مراجع و منابع این مقاله:

لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :
  • Alfieri O, Mayosi BM, Park SJ, Sarrafzadegan N, Virmani R. ...
  • Ozturk HS, Cimen MY, Cimen OB, Kacmaz M, Durak I. ...
  • Anwaruddin S, Askari AT, Topol EJ. Redefining risk in acute ...
  • Ghayour-Mobarhan M, Alamdari DH, Moohebati M, Sahebkar A, Nematy M, ...
  • Harrison D, Griendling KK, Landmesser U, Hornig B, Drexler H. ...
  • Criqui MH, Denenberg JO, Ix JH, McClelland RL, Wassel CL, ...
  • Virmani R, Burke AP, Farb A, Kolodgie FD. Pathology of ...
  • Raffetto JD, Khalil RA. Matrix metalloproteinases and their inhibitors in ...
  • Goldstein JA, Demetriou D, Grines CL, Pica M, Shoukfeh M, ...
  • Meydani M. Vitamin E modulation of cardiovascular disease. Ann N ...
  • Rajala MW, Obici S, Scherer PE, Rossetti L. Adipose-derived resistin ...
  • Talman AH, Psaltis PJ, Cameron JD, Meredith IT, Seneviratne SK, ...
  • Qiao XZ, Yang YM, Xu ZR, Yang LA. Relationship between ...
  • Charo IF, Ransohoff RM. The many roles of chemokines and ...
  • George SJ, Johnson J. Atherosclerosis: Molecular and Cellular Mechanisms. Hoboken, ...
  • Bokarewa M, Nagaev I, Dahlberg L, Smith U, Tarkowski A. ...
  • Jung HS, Park KH, Cho YM, Chung SS, Cho HJ, ...
  • Kaser S, Kaser A, Sandhofer A, Ebenbichler CF, Tilg H, ...
  • Burnett MS, Lee CW, Kinnaird TD, Stabile E, Durrani S, ...
  • Kawanami D, Maemura K, Takeda N, Harada T, Nojiri T, ...
  • Patel L, Buckels AC, Kinghorn IJ, Murdock PR, Holbrook JD, ...
  • Yang RZ, Huang Q, Xu A, McLenithan JC, Eisen JA, ...
  • Fruhbeck G, Salvador J. Role of adipocytokines in metabolism and ...
  • Li R, Chen LZ, Zhao SP, Huang XS. Inflammation Activation ...
  • Darabi F, Aghaei M, Movahedian A, Elahifar A, Pourmoghadas A, ...
  • Weaver WD, Simes RJ, Betriu A, Grines CL, Zijlstra F, ...
  • Pasterkamp G, Schoneveld AH, Hijnen DJ, de Kleijn DP, Teepen ...
  • Unal I. Defining an Optimal Cut-Point Value in ROC Analysis: ...
  • Kotani T, Takeuchi T, Takai S, Yoshida S, Hata K, ...
  • Anzai A, Maekawa Y, Kodaira M, Mogi S, Arai T, ...
  • Libby P. Inflammation in atherosclerosis. Arterioscler Thromb Vasc Biol ۲۰۱۲; ...
  • Madrigal-Matute J, Rotllan N, Aranda JF, Fernandez-Hernando C. MicroRNAs and ...
  • Lendon CL, Davies MJ, Born GV, Richardson PD. Atherosclerotic plaque ...
  • Moreno PR, Falk E, Palacios IF, Newell JB, Fuster V, ...
  • DeClercq V, Taylor C, Zahradka P. Adipose tissue: The link ...
  • Modi KA, Nylk TM, Sheridan FM. Medical management of acute ...
  • Komorowski J, Pasieka Z, Jankiewicz-Wika J, Stepien H. Matrix metalloproteinases, ...
  • Ashok BT, Ali R. The aging paradox: free radical theory ...
  • Bartel DP. MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell ۲۰۰۴; ...
  • Bauvois B. New facets of matrix metalloproteinases MMP-۲ and MMP-۹ ...
  • Lu P, Takai K, Weaver VM, Werb Z. Extracellular matrix ...
  • Chen CC, Li TC, Li CI, Liu CS, Wang HJ, ...
  • Bednarska-Makaruk M, Graban A, Wisniewska A, Lojkowska W, Bochynska A, ...
  • He L, Hannon GJ. MicroRNAs: Small RNAs with a big ...
  • Wightman B, Ha I, Ruvkun G. Posttranscriptional regulation of the ...
  • Rao V, Kiran R. Evaluation of correlation between oxidative stress ...
    • نمایش کامل مراجع