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Using rats as a research model to investigate the effect of human adenovirus ۳۶ on weight gain

محل انتشار: مجله آریا آترواسکلروز، دوره: 13، شماره: 4
سال انتشار: 1396
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 140

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https://civilica.com/doc/1504741

شناسه ملی سند علمی:

JR_RYA-13-4_002

تاریخ نمایه سازی: 2 شهریور 1401

چکیده مقاله:

BACKGROUND: Recent evidence has shown a positive correlation between obesity and viral infections with a particular emphasis on the human adenovirus-۳۶ (Ad-۳۶). Ad-۳۶ is the first human virus that may increase adiposity in animals, and it is considered as a possible risk factor for obesity in humans; however, the results were not consistent across all the studies. The present study was conducted to examine the influence of Ad-۳۶ infection on obesity in a rat model. METHODS: Eight-week-old male Wistar rats weighing ۱۷۰-۲۴۰ gram (g), were randomly divided into two groups, infection group (۴۸ rats) and a control group (۱۲ rats). The rats in the infection group were infected with human Ad-۳۶. All rats were given free access to a normal chow diet and water. They were weighed weekly. RESULTS: The mean ± standard deviation (SD) body weights were ۲۲۹.۰ ± ۲۵.۹ g and ۲۳۲.۳ ± ۱۶.۶ g in the infection and control groups, respectively at the time of infection. The mean ± SD body weight of the infection group (۳۰۴.۰ ± ۳۹.۰ g) was higher than the control group (۳۰۱.۰ ± ۳۶.۵ g) at ۱۲ weeks post-infection (P = ۰.۸۲). Although two groups had approximately same food intakes, the mean change in body weight was greater in the infection group than the control group (۷۵.۸ ± ۲۷.۹ g vs. ۷۰.۸ ± ۲۴.۵ g) but it was not significant (P = ۰.۵۷). CONCLUSION:We did not find a statistically significant association between weight gain and Ad-۳۶ infection in the rat model. It seems that longer follow-up duration is needed to develop a significant weight gain in the infected rats. Rats can be used as a good animal model for further investigations about Ad-۳۶-induced obesity, provided not to rely merely on weight measurements. Evaluating body composition or histopathological assessments are suggested. 

کلیدواژه ها:

Adenovirus Infections ، Weight Gain ، Wistar Rats

نویسندگان

Fatemeh Shirani

PhD Candidate, Nutrition and Metabolic Diseases Research Cente AND School of Paramedical, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Ali Teimoori

Assistant Professor, Health Research Institute, Infectious and Tropical Diseases Research Center AND School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Mohammad Rashno

Assistant Professor, Department of Immunology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Seyed Mahmoud Latifi

Lecturer, Diabetes Research Center AND Department of Statistics and Epidemiology, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Majid Karandish

Professor, Nutrition and Metabolic Diseases Research Center AND School of Paramedical, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

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  • World Health Organization. Obesity and overweight [Online]. [cited ۲۰۱۵]; Available ...
  • Farshidi H, Nikparvar M, Zare S, Bushehri E, Eghbal Eftekhaari ...
  • Ponterio E, Gnessi L. Adenovirus ۳۶ and obesity: An overview. ...
  • Hegde V, Dhurandhar NV. Microbes and obesity-interrelationship between infection, adipose ...
  • Dhurandhar NV. Infectobesity: Obesity of infectious origin. J Nutr ۲۰۰۱; ...
  • Genoni G, Prodam F, Marolda A, Giglione E, Demarchi I, ...
  • Kapila M, Khosla P, Dhurandhar NV. Novel short-term effects of ...
  • Sabin MA, Burgner D, Atkinson RL, Pei-Lun LZ, Magnussen CG, ...
  • Dhurandhar NV. Is obesity caused by an adenovirus? Expert Rev ...
  • Pasarica M, Mashtalir N, McAllister EJ, Kilroy GE, Koska J, ...
  • Xu MY, Cao B, Wang DF, Guo JH, Chen KL, ...
  • Esposito S, Preti V, Consolo S, Nazzari E, Principi N. ...
  • Harrison SC. Virology. Looking inside adenovirus. Science ۲۰۱۰; ۳۲۹(۵۹۹۵): ۱۰۲۶-۷ ...
  • Na HN, Park S, Jeon HJ, Kim HB, Nam JH. ...
  • Voss JD, Atkinson RL, Dhurandhar NV. Role of adenoviruses in ...
  • Atkinson RL, Dhurandhar NV, Allison DB, Bowen RL, Israel BA, ...
  • Goossens VJ, deJager SA, Grauls GE, Gielen M, Vlietinck RF, ...
  • Ehsandar S, Zarkesh M, Daneshpour MS, Bandehpour M, Azizi F, ...
  • Pasarica M, Shin AC, Yu M, Ou Yang HM, Rathod ...
  • Nasri HR, Shahouzehi B, Masoumi-Ardakani Y, Iranpour M. Effects of ...
  • Atkinson RL. Current status of the field of obesity. Trends ...
  • Seidell JC, Halberstadt J. The global burden of obesity and ...
  • Rashidi H, Payami SP, Latifi SM, Karandish M, Moravej AA, ...
  • Vieira PN, Silva MN, Mata J, Coutinho SR, Santos TC, ...
  • Mann T, Tomiyama AJ, Westling E, Lew AM, Samuels B, ...
  • Huttunen R, Syrjanen J. Obesity and the risk and outcome ...
  • Serrano M, Moreno M, Bassols J, Moreno-Navarrete JM, Ortega F, ...
  • Ponterio E, Cangemi R, Mariani S, Casella G, De Cesare ...
  • Dhurandhar NV. A framework for identification of infections that contribute ...
  • Bil-Lula I, Stapor S, Sochocka M, Wolyniec M, Zatonska K, ...
  • Trovato GM, Martines GF, Garozzo A, Tonzuso A, Timpanaro R, ...
  • Dhurandhar NV, Kulkarni P, Ajinkya SM, Sherikar A. Effect of ...
  • Almgren M, Atkinson R, He J, Hilding A, Hagman E, ...
  • Parra-Rojas I, Del Moral-Hernandez O, Salgado-Bernabe AB, Guzman-Guzman IP, Salgado-Goytia ...
  • Trovato GM, Martines GF, Trovato FM, Pirri C, Pace P, ...
  • Voss JD, Burnett DG, Olsen CH, Haverkos HW, Atkinson RL. ...
  • Liu C, Xiao Y, Zhang J, Ren L, Li J, ...
  • Atkinson RL. Viruses as an etiology of obesity. Mayo Clin ...
  • Na HN, Kim J, Lee HS, Shim KW, Kimm H, ...
  • Iannaccone PM, Jacob HJ. Rats! Dis Model Mech ۲۰۰۹; ۲(۵-۶): ...
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