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مقالات فارسیISIکنفرانسهاژورنالها

Comparative effects of carbohydrate versus fat restriction on metabolic profiles, biomarkers of inflammation and oxidative stress in overweight patients with Type ۲ diabetic and coronary heart disease: a randomized clinical trialComparative effects of car

محل انتشار: مجله آریا آترواسکلروز، دوره: 12، شماره: 6
سال انتشار: 1395
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 137

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لینک ثابت به این مقاله:
https://civilica.com/doc/1504776

شناسه ملی سند علمی:

JR_RYA-12-6_003

تاریخ نمایه سازی: 2 شهریور 1401

چکیده مقاله:

BACKGROUND: This study was conducted to establish the comparative effects of carbohydrate versus fat restriction on metabolic indices in Type ۲ diabetic (T۲D) patients with coronary heart disease (CHD). METHODS: This randomized, clinical trial was done among ۵۶ overweight persons with T۲D and CHD aged ۴۰-۸۵ years old. The patients were randomly allocated to take either a high-carbohydrate (HC) diet (۶۰-۶۵% carbohydrates and ۲۰-۲۵% fats) (n = ۲۸) or a restricted carbohydrate (RC) diet (۴۳-۴۹% carbohydrate and ۳۶-۴۰% fats) (n = ۲۸) for ۸ weeks to determine metabolic status. RESULTS: After ۸ weeks of treatment, RC diet decreased fasting plasma glucose (FPG) (−۱۱.۵ ± ۲۸.۳ vs. +۷.۰ ± ۲۶.۹ mg/dl, P = ۰.۰۱۰) and high-sensitivity C-reactive protein (hs-CRP) (−۵۶۴.۳ ± ۱۲۸۰.۱ vs. +۲۸۶.۱ ± ۱۷۸۹.۲ ng/ml, P = ۰.۰۴۰) compared with a HC diet. Moreover, compared with a HC diet, RC diet increased total antioxidant capacity (TAC) (+۲۷۴.۸ ± ۱۱۱.۵ vs. +۲۰.۲ ± ۸۲.۵ mmol/l, P < ۰.۰۰۱) and glutathione (GSH) levels (+۵۱.۶ ± ۱۱۱.۵ vs. −۳۲.۶ ± ۸۸.۵ µmol/l, P = ۰.۰۰۳). No significant alterations between the two groups were found in terms of their effect on other metabolic profiles. CONCLUSION: RC diet in overweight T۲D with CHD had beneficial effects on FPG, hs-CRP, TAC, and GSH values. 

کلیدواژه ها:

Carbohydrate Restriction ، Metabolic Status ، Type ۲ Diabetes Mellitus ، Coronary Heart Disease ، Obesity

نویسندگان

Fariba Raygan

Department of Cardiology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran

Fereshteh Bahmani

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran

Ebrahim Kouchaki

Physiology Research Center AND Department of Neurology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran

Esmat Aghadavod

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran

Sahar Sharifi

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran

Elmira Akbari

Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran

Akbar Heidari

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran

Zatollah Asemi

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran

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