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مقالات فارسیISIکنفرانسهاژورنالها

Predictive role of adiponectin and high-sensitivity C-reactive protein for prediction of cardiovascular event in an Iranian cohort study: The Isfahan Cohort Study

محل انتشار: مجله آریا آترواسکلروز، دوره: 12، شماره: 3
سال انتشار: 1395
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 97

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لینک ثابت به این مقاله:
https://civilica.com/doc/1504803

شناسه ملی سند علمی:

JR_RYA-12-3_004

تاریخ نمایه سازی: 2 شهریور 1401

چکیده مقاله:

BACKGROUND: Numerous studies have been conducted on the predictive effects of high-sensitivity C-reactive protein (hs-CRP) on cardiovascular events. Few studies have been conducted to investigate the effects of adiponectin for the prediction of the incident of cardiovascular events in the Middle East area. This study compared the predictive effect of hs-CRP and adiponectin on healthy volunteers for the prediction of cerebrovascular disease (CVD). METHODS: This nested case-control in original Isfahan Cohort Study (ICS) was conducted from ۲۰۰۱ to ۲۰۱۱. Participants were selected from ICS. The case group included participants with CVD while the control group included participants without CVD. The level of hs-CRP and adiponectin was measured in the blood samples collected in the year ۲۰۰۷. Thereafter, the statistical analyses were performed to determine the predictive value of hs-CRP and adiponectin in CVD prediction. RESULTS: The results showed that before the elimination of diabetes effect; there was a significant difference between the two groups, in terms of the mean of adiponectin (P = ۰.۰۱۹) and no significant difference was observed in hs-CRP levels (P = ۰.۶۷۳). However, after eliminating the factor of diabetes, there was no significant difference between the case and control groups in adiponectin and hs-CRP levels (P = ۰.۱۸۴, P = ۰.۹۴۶). The results showed that the odds ratio (OR) of the adiponectin level was ۰.۸۷۹ [۹۵% confidence interval (CI): ۰.۷۱۹-۱.۰۷۵, P = ۰.۲۱۰] while the OR of hs-CRP was ۱.۰۴۵ (۹۵% CI: ۰.۹۲۲-۱.۱۸۵, P = ۰.۴۹۱). Furthermore, it was shown that after adjustment for age, sex, and diabetes; the OR of adiponectine was ۰.۸۷۵ (۹۵% CI: ۰.۷۰۱-۱.۰۹۱, P = ۰.۲۳۵) and that of hs-CRP was ۱.۰۶۸ (۹۵% CI: ۰.۹۳۵-۱.۲۱۹, P = ۰.۳۳۳). CONCLUSION: The results show that adiponectin and hs-CRP cannot be predictors for cardiovascular events in a healthy population. Risk factors such as diabetes limit the use of adiponectin as a CVD predictor. 

کلیدواژه ها:

Adiponectin ، High-Sensitivity C-Reactive Protein ، Cardiovascular Disease

نویسندگان

Davoud Kazemi-Saleh

Professor, Atherosclerosis Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

Pooya Koosha

Resident, Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Masoumeh Sadeghi

Professor, Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Nizal Sarrafzadegan

Professor, Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Reza Karbasi-Afshar

Assistant Professor, Atherosclerosis Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

Mansoureh Boshtam

Research Assistant, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Shahram Oveis-Gharan

Assistant Professor, Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan AND Department of Neurology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

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