Can cardiac rehabilitation programs improve functional capacity and left ventricular diastolic function in patients with mechanical reperfusion after ST elevation myocardial infarction?: A double-blind clinical trial

BACKGROUND: Current guidelines recommend cardiac rehabilitation programs (CRP) as a means to improve functional status of patients after coronary revascularization. However, research supporting this recommendation has been limited and positive effects of CRP on diastolic function are controversial. The aim of this study was to examine the effects of an ۸-week CRP on left ventricular diastolic function.    METHODS: This randomized, clinical trial included ۲۹ men with ST elevation myocardial infarction (MI) who had received reperfusion therapy, i.e. coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI). They were randomized to a training group (n = ۱۵; mean age: ۵۴.۲ ± ۹.۰۴ years old) and a control group (n = ۱۴; mean age: ۵۱.۷۱ ± ۶.۹۸ years old). Patients in the training group performed an ۸-week CRP with an intensity of ۶۰-۸۵% of maximum heart rate. Exercise sessions lasted ۶۰-۹۰ minutes and were held three times a week. At the start and end of the study, all patients performed symptom-limited exercise test based on Naughton treadmill protocol. Pulsed-wave Doppler echocardiography was also used to determine peak velocity of early (E) and late (A) waves, E/A ratios, and the deceleration time of E (DT).    RESULTS: Left ventricular diastolic indices (E, A, E/A ratio, DT) did not change significantly after the CRP. Compared to baseline, patients in the training group had significant improvements in functional capacity (۸.۳۰ ± ۱.۳۰ vs. ۹.۷ ± ۱.۷) and maximum heart rate (۱۱۸.۵۰ ± ۲۴.۴۸ vs. ۱۲۶.۸۵ ± ۲۲.۷۵). Moreover, resting heart rate of the training group was significantly better than the control group at the end of the study (۷۵.۳۶ ± ۷.۹۴ vs. ۷۹.۸۰ ± ۷.۶۷; P < ۰.۰۰۱).    CONCLUSION: An ۸-week CRP in post-MI patients revascularized with PCI or CABG led to improved exercise capacity. However, the CRP failed to enhance diastolic function.      Keywords: Cardiac Rehabilitation, Diastolic Function, Functional Capacity, Post-Myocardial Patients.