Changes in GDF-۱۵ Serum Levels in Response to the Interaction of Aerobic Training with Green Tea Extract Supplementation Reduce Cardiovascular Risk Factors in Obese Men with Type ۲ Diabetes

Obesity and type ۲ diabetes are major public health issues worldwide, contributing to increased cardiovascular morbidity and mortality. Although pharmacologic modality is the mainstay treatment of diabetes, remedies using plants have stimulated a new interest in research. On the other hand, it has been shown that the use of exercise along with herbal supplements is one of the proposed methods to control obesity and its complications such as diabetes and insulin resistance and inflammation.The aim of this study was to investigate the response of serum levels of growth differentiation factor ۱۵ (GDF-۱۵) to the interaction of green tea extract supplementation with aerobic training (AE) for eight weeks on some cardiovascular risk factors in obese men with type ۲ diabetes. is.۴۰ obese men with type ۲ diabetes after initial assessments including measurement of some anthropometric and physiological features randomly divided into ۵ groups of eight, ۱) supplement, ۲) supplement + Aerobic training, ۳) placebo, ۴) placebo + AT and ۵) AT were divided. Anthropometric, physiological, lipid profile and serum levels of GDF-۱۵ were evaluated in two stages of pre-test and post-test.Data analysis showed that the decrease in GDF-۱۵ levels in the groups of supplement, supplement + AT, placebo + AT and AT was significantly related to mean weight, BMI, WHR percentage of fat, physiological characteristics including systolic blood pressure, Diastole, resting heart rate, lipid profiles including HDL, LDL, triglycerides and cholesterol, and insulin resistance (P≤ ۰.۰۵), so that this association was greater in the supplement + AT groups than in the other groups ( P≤ ۰.۰۵).Based on the results, it can be said that reducing GDF-۱۵ levels due to AT + green tea supplementation is one of the effective strategies in reducing cardiovascular risk factors in obese men with type ۲ diabetes.