Investigation of medicinal applications of Maclura pomifera extract

Background and Objective: Maclura pomifera (Rafin.) Schneider, known as osage orange is a north american native plant, which has multiple applications in herbal medicine. The extract of this plant has many therapeutic effects including antimicrobial, anti-tumor, antiinflammation etc. that discussed in this study.Materials and Methods: For this study, the keywords "Maclura pomifera", "osage orange ", " herbal medicine ", and "plant extract" in the databases PubMed and Google Scholar between ۲۰۰۲ and ۲۰۲۱ were searched and ۲۰ articles were chosen, studied and analyzed.Results: Due to the increased resistance of microbes to antibiotics, the need for antimicrobial plants is increasing. Maclura pomifera is one of the plants with antimicrobial properties that can affect all microbes, especially Gram-negative bacteria and fungi. This plant also has antitumor, anti-inflammatory, anti-oxidant, anti-aging, antiviral, anti-fungal, anti-ulcerogenic, anti-diabetic, and anti-nociceptive effects, which can be used as a substance with many amazing therapeutic applications.Conclusion: These results suggest that the extract of Maclura pomifera can be used in clinical medicine as a remedial agent, which can be substituted for chemical drugs or help them in treatment of diseases.