Treadmill training attenuates pyroptosis in rats with cerebral ischemia/reperfusion injury
محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 25، شماره: 10
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 141
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شناسه ملی سند علمی:
JR_IJBMS-25-10_008
تاریخ نمایه سازی: 11 مهر 1401
چکیده مقاله:
Objective(s): Few studies have investigated the mechanism by which exercise training promotes neural repair during rehabilitation after stroke. In this study, we evaluated the neuroprotective effects of exercise training and pyroptosis-associated factors in the penumbra and elucidated the possible mechanisms.Materials and Methods: Neurological deficits, body weight, and the infarct size were evaluated, and haematoxylin-eosin (HE) staining was performed. Western blotting and immunofluorescence staining were used to assess NOD-like receptor family pyrin domain-containing ۳ (NLRP۳) and caspase-۱ levels. Interleukin-۱β (IL-۱β) and interleukin-۱۸ (IL-۱۸) levels were assessed by enzyme-linked immunosorbent assay (ELISA). B-cell lymphoma ۲ (bcl-۲) and bax protein levels were measured by Western blotting, and terminal deoxynucleotidyl transferase dUTP nick-end labelling (TUNEL) staining was used to evaluate apoptotic cells.Results: Exercise training decreased neurological deficits and the infarct size in MCAO rats Moreover, NLRP۳ inflammasome-associated protein levels in the peri-infarct cortex were decreased by exercise training. Exercise training decreased the serum concentrations of IL‑۱β and IL‑۱۸, upregulated bcl-۲, downregulated bax, and reduced the TUNEL index. Conclusion: Exercise training suppresses NLRP۳ inflammasome activity and inhibits pyroptosis to protect against cerebral ischaemic injury. Exercise training can also suppress apoptosis, which may be the target of exercise-induced neuroprotection, thereby reducing brain injury.
کلیدواژه ها:
Apoptosis ، Cerebral infarction ، Exercise ، NLR Family ، Protein ، Pyroptosis ، Pyrin domain containing ۳
نویسندگان
Fang Luo
Tongde Hospital of Zhejiang Province, No. ۲۳۴, Gucui Road, Hangzhou, Zhejiang, China
Mingjin Zhu
Tongde Hospital of Zhejiang Province, No. ۲۳۴, Gucui Road, Hangzhou, Zhejiang, China
Kunkun Lv
Tongde Hospital of Zhejiang Province, No. ۲۳۴, Gucui Road, Hangzhou, Zhejiang, China
Di Sun
Tongde Hospital of Zhejiang Province, No. ۲۳۴, Gucui Road, Hangzhou, Zhejiang, China
Guifen Yang
Tongde Hospital of Zhejiang Province, No. ۲۳۴, Gucui Road, Hangzhou, Zhejiang, China
Guoyuan Pan
Tongde Hospital of Zhejiang Province, No. ۲۳۴, Gucui Road, Hangzhou, Zhejiang, China
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