Neonatal Multisystem Inflammatory Syndrome Consequent to Perinatal SARS-COVID-۲- Infection: A Narrative Review Study
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 206
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شناسه ملی سند علمی:
JR_JOGCR-7-6_001
تاریخ نمایه سازی: 12 مهر 1401
چکیده مقاله:
Several studies have described multisystem inflammatory syndrome (MIS) in children, but very few investigations presented this syndrome among neonates (MIS-N). The present study has reviewed the current knowledge about MIS-N, its etiology, symptoms, and outcomes to attract special attention with an eye on earlier diagnosis and treatment of newborns affected by perinatal SARS-CoV-۲-infection. A narrative review study was conducted (Tehran, Iran, ۲۰۲۱). All types of full English articles (up to October ۱ ۲۰۲۱) were included. Detailed research on academic search engines was performed. The implemented Mesh-based keywords were "SARS-COVID-۲" OR "COVID-۱۹" OR "coronavirus" AND "Neonate" OR "Neonatal" OR "Newborn" AND "Multisystem Inflammatory Syndrome" OR "MIS-N" OR "inflammatory response syndrome" AND "Pregnancy" OR "Perinatal" OR "prenatal". Finally, ۱۵ Full-text articles were included that met the eligibility criteria. Available data related to the disease, its etiology, presentations, and its outcome were collected and discussed. The cause of MIS-N is the transmission or production of SARS-CoV۲ antibodies in response to SARS-CoV۲ infection. By involving different organs, the clinical manifestations of MIS-N may mimic sepsis, toxic shock syndrome, RDS, Kawasaki disease, necrotizing enterocolitis, myocarditis, meningitis/encephalitis, aortic thrombosis, ETC. Besides the clinical presentations, detecting reactive anti-SARS-CoV-۲ IgG antibodies could be a notable clue in MIS-N diagnosis. Supportive therapy, suppressing the autoimmune and inflammatory responses, anti-platelet agents, and anticoagulants were reported as effective therapeutic agents to improve the outcome. The present study highlighted the possibility of MIS-N as an infrequent but severe syndrome consequent to perinatal COVID-۱۹ infection. Although the diagnosis is still controversial, clinical suspicion, laboratory findings, and early treatment initiation could improve the outcome of this immunological disease.
کلیدواژه ها:
نویسندگان
Sedigheh Hantoushzadeh
Vali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran
Taraneh Geran Orimi
Department of Perinatology, Vali-E-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
Mohammad Reza Zarkesh
Department of Neonatology, Yas Women Hospital, Tehran University of Medical Sciences, Tehran, Iran
Tahmineh Geran Orimi
Blood Transfusion Organization, Mazandaran, Iran
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