Effects of Escherichia coli strain Nissle ۱۹۱۷ on goldfish(Carassius auratus) tissues histomorphology challenged with arsenic

Background and Aim : Arsenic contamination in natural water resources has become a greatdisaster throughout the world which poses serious health problem. The current study wasperformed to evaluate the protective effects of Escherichia coli strain Nissle ۱۹۱۷ (EcN) againstarsenic (As) exposure on the intestine, kidney, liver, gill and skin histomorphology in goldfish.Methods : Fish were fed with different doses (۰, ۱۰۶, ۱۰۷, and ۱۰۸ CFU g-۱) EcN for ۸۰ days andthen challenged with As for ۹۶ h.Results : Results showed that supplemented EcN did not have any side effects on various vitalorgans. It was also observed that the damages to kidney, liver, gill, and skin were pronounced infish exposed to As. However, the histopathological damages in fish tissues induced by As wereless pronounced in the EcN treated groups compared to the fish fed with the basal diet.Conclusion : These findings indicate that EcN had potential for ameliorating the toxicity inducedby As.