The effect of platelet-rich plasma on the improvement of pregnancy results in repeated implantation failure: A randomized controlled trial

Background: The success rate of infertility treatment depends on many different factors. Objective: This study aimed to determine the effect of platelet-rich plasma (PRP) on the improvement of pregnancy outcomes in participants with repeated implantation failure. Materials and Methods: The study is a randomized triple-blind clinical trial. The study population was ۱۱۸ women with repeated implantation failure during assisted reproductive technology treatment at Tabriz Jihad-e Daneshgahi ART Center from May ۲۰۱۷ to December ۲۰۱۹. Intervention: Intrauterine injection of autologous PRP. Standard treatment of fetal transfer to the uterine cavity was performed without intrauterine PRP injection in the control group: After ۴ wk, the level of β-human chorionic gonadotropin hormone in participants' blood was measured. Results: Comparing the effect of intrauterine injection of PRP in ۲ groups showed the level of β-human chorionic gonadotropin positive in the intervention group was ۲۱ (۴۳.۸%), in the control group was ۱۲ (۲۶.۱%), odds ratio = ۲.۲۰ (۰.۹۲-۵.۲۶) and p = ۰.۰۷۳. Conclusion: The therapeutic effect in the intervention group compared to the control regarding the outcome of a successful pregnancy showed that intrauterine injection of PRP can be effective in improving pregnancy outcomes, although this improvement is not significant.