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مقالات فارسیISIکنفرانسهاژورنالها

Isoflavone daidzein ameliorates renal dysfunction and fibrosis in a postmenopausal rat model: Intermediation of angiotensin AT۱ and Mas receptors and microRNAs ۳۳a and ۲۷a

محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 25، شماره: 11
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 182

فایل این مقاله در 9 صفحه با فرمت PDF قابل دریافت می باشد

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لینک ثابت به این مقاله:
https://civilica.com/doc/1540937

شناسه ملی سند علمی:

JR_IJBMS-25-11_005

تاریخ نمایه سازی: 30 مهر 1401

چکیده مقاله:

Objective(s): Chronic kidney disease (CKD), accompanied by renal dysfunction, fibrosis, and apoptosis, is highly prevalent in postmenopausal women. We tested the hypothesis that isoflavone daidzein may ameliorate renal dysfunction and fibrosis through angiotensin II type ۱ (AT۱R) and angiotensin ۱-۷ (MasR) receptors in association with microRNAs ۳۳a and ۲۷a.Materials and Methods: Two weeks before the initiation of the experiments, rats (n=۸۴) underwent ovariectomy (OVX). Then, unilateral ureteral obstruction (UUO) was performed in OVX rats, and animals were allocated to the following groups (n=۲۱): sham vehicle (dimethyl sulfoxide; DMSO ۱%), UUO vehicle, UUO+۱۷β-estradiol (E۲), and UUO+daidzein. Each group encompassed three subgroups (n=۷) treated with saline, A۷۷۹ (MasR antagonist), or losartan (AT۱R antagonist) for ۱۵ days. The fractional urine excretion of sodium (FENa+) and potassium (FEK+), renal failure index (RFI), renal interstitial fibrosis (RIF index), glomerulosclerosis, miR-۳۳a, and miR-۲۷a expressions and their target genes were analyzed. Apoptosis was measured via cleaved caspase-۳ immunohistochemistry.Results: UUO increased kidney weight, FENa+, FEK+, urine calcium, RFI, RIF index, glomerulosclerosis, and cleaved caspase-۳. Moreover, expression of renal miR-۳۳a and miR-۲۷a, collagen۳A۱ mRNA, and protein were up-regulated post-UUO. Daidzein treatment alleviated the harmful effects of UUO especially in co-treatment with losartan. They also masked the anticipated worsening effects of A۷۷۹ on UUO.Conclusion: Compared with E۲, daidzein efficiently ameliorated renal dysfunction, fibrosis, and apoptosis through modulation of miR-۳۳a and miR-۲۷a expression and their crosstalk with AT۱R and MasR. Therefore, daidzein might be a promising candidate for treating CKD in postmenopausal and older women. 

کلیدواژه ها:

Angiotensin receptor ، Apoptosis ، Daidzein ، microRNAs ، Ovariectomy ، Renal fibrosis

نویسندگان

Majid Askaripour

Department of Physiology and Pharmacology, and Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran

Hamid Najafipour

Department of Physiology and Pharmacology, and Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran

Shadan Saberi

Department of Physiology and Pharmacology, Afzalipour Medical Faculty and Physiology Research Centre, Kerman University of Medical Sciences, Kerman, Iran

Saleh Yazdani

VIB-KU Leuven Center for Microbiology, Leuven, Belgium

Saeideh Jafarinejad-Farsangi

Physiology Research Centre, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran

Soodeh Rajabi

Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran

Elham Jafari

Pathology and Stem Cell Research Center, Department of Pathology, Kerman University of Medical Sciences, Kerman, Iran

Paul Proost

Laboratory of Molecular Immunology, Department of Microbiology, Immunology, and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium

Sofie Struyf

Laboratory of Molecular Immunology, Department of Microbiology, Immunology, and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium

Fariba Poosti

Laboratory of Molecular Immunology, Department of Microbiology, Immunology, and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium

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  • Suzuki H, Kondo K. Chronic kidney disease in postmenopausal women. ...
  • Djudjaj S, Boor P. Cellular and molecular mechanisms of kidney ...
  • Martínez-Klimova E, Aparicio-Trejo OE, Tapia E, Pedraza-Chaverri J. Unilateral ureteral ...
  • Chung AC-K, Lan HY. MicroRNAs in renal fibrosis. Front Physiol ...
  • Price NL, Miguel V, Ding W, Singh AK, Malik S, ...
  • Hou X, Tian J, Geng J, Li X, Tang X, ...
  • AlQudah M, Hale TM, Czubryt MP. Targeting the renin-angiotensin-aldosterone system ...
  • Pinheiro SVB, Ferreira AJ, Kitten GT, da Silveira KD, da ...
  • Zimmerman DL, Zimpelmann J, Xiao F, Gutsol A, Touyz R, ...
  • Leete J, Gurley S, Layton AT. Modeling sex differences in ...
  • Kattah AG, Smith CY, Rocca LG, Grossardt BR, Garovic VD, ...
  • Garate-Carrillo A, Gonzalez J, Ceballos G, Ramirez-Sanchez I, Villarreal F. ...
  • Fait T. Menopause hormone therapy: Latest developments and clinical practice. ...
  • Petrine JC, Del Bianco‐Borges B. The influence of phytoestrogens on ...
  • Moreira AC, Silva AM, Santos MS, Sardao VA. Phytoestrogens as ...
  • Soumyakrishnan S, Divya T, Kalayarasan S, Sriram N, Sudhandiran G. ...
  • Tomar A, Kaushik S, Khan SI, Bisht K, Nag TC, ...
  • Jitmana R, Raksapharm S, Kijtawornrat A, Saengsirisuwan V, Bupha-Intr T. ...
  • Ebrahimi MN, Khaksari M, Sepehri G, Karam GA, Raji-Amirhasani A, ...
  • Maghool F, Khaksari M. Differences in brain edema and intracranial ...
  • Kaeidi A, Taghipour Z, Allahtavakoli M, Fatemi I, Hakimizadeh E, ...
  • Teixeira LB, Parreiras-e-Silva LT, Bruder-Nascimento T, Duarte DA, Simões SC, ...
  • Dixon A, Maric C. ۱۷β-Estradiol attenuates diabetic kidney disease by ...
  • Dobrek Ł, Skowron B, Baranowskaa A, Płoszaj K, Bądziul D, ...
  • Zhou T-B, Ou C, Qin Y-H, Lei F-Y, Huang W-F, ...
  • Kim EY, Yazdizadeh Shotorbani P, Dryer SE. Trpc۶ inactivation confers ...
  • Li Y-f, Xu B-y, An R, Du X-f, Yu K, ...
  • Rajabi S, Najafipour H, Jafarinejad Farsangi S, Joukar S, Beik ...
  • Kostopoulou F, Malizos KN, Papathanasiou I, Tsezou A. MicroRNA-۳۳a regulates ...
  • Ma Y, Yu S, Zhao W, Lu Z, Chen J. ...
  • Wu L, Song W-y, Xie Y, Hu L-l, Hou X-m, ...
  • Tseng TY, Stoller ML. Obstructive uropathy. Clinics in geriatric medicine. ...
  • Li W, Lu Y, Lou Y, Zhao S, Cui W, ...
  • Bhaskaran M, Reddy K, Radhakrishanan N, Franki N, Ding G, ...
  • Misseri R, Meldrum KK. Mediators of fibrosis and apoptosis in ...
  • Meng H, Fu G, Shen J, Shen K, Xu Z, ...
  • Colafella KMM, Denton KM. Sex-specific differences in hypertension and associated ...
  • Askaripour M, Najafipour H, Saberi S, Jafari E, Rajabi S. ...
  • Fredette NC, Meyer MR, Prossnitz ER. Role of GPER in ...
  • Sobrino A, Vallejo S, Novella S, Lázaro-Franco M, Mompeón A, ...
  • Wang X, Tan Y, Xu B, Lu L, Zhao M, ...
  • Gohar EY. G protein-coupled estrogen receptor ۱ as a novel ...
  • Adamcova M, Kawano I, Simko F. The impact of microRNAs ...
  • Cao M, Bai L, Wang D, Zhai Q, Li Y, ...
  • Wu L, Wang Q, Guo F, Ma X, Ji H, ...
  • Jennewein C, von Knethen A, Schmid T, Brüne B. MicroRNA-۲۷b ...
  • Wu L, Wang Q, Guo F, Ma X, Wang J, ...
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